The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision.

The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision.

Loss of the PTEN tumor suppressor is a common occurrence in human prostate cancer, particularly in advanced disease. In keeping with its role as a pivotal upstream regulator of the phosphatidylinositol 3-kinase signaling pathway, experimentally-induced deletion of Pten in the murine prostate invaria...

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Bibliographic Details
Main Authors: H Artee Luchman, Hallgrimur Benediktsson, Michelle L Villemaire, Alan C Peterson, Frank R Jirik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2597775?pdf=render

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