Paraneoplastic cerebellar degeneration associated with anti-Yo antibodies in an ovarian cancer case: A case report
Paraneoplastic neurologic syndromes (PNS) are a rare heterogeneous group of disorders associated with malignancy that can result in significant functional impairment. One syndrome in particular, paraneoplastic cerebellar degeneration (PCD), may be severely disabling. PCD is a rare neurological syndr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578920301612 |
| _version_ | 1818589373110681600 |
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| author | Sandra Deac Mihaela Marioara Stana Andrei Dan Havasi Calin Cainap Anca-Raluca Popita Ana Maria Bordeianu Simona Cainap Madalina Bota Ovidiu Vasile Bochis |
| author_facet | Sandra Deac Mihaela Marioara Stana Andrei Dan Havasi Calin Cainap Anca-Raluca Popita Ana Maria Bordeianu Simona Cainap Madalina Bota Ovidiu Vasile Bochis |
| author_sort | Sandra Deac |
| collection | DOAJ |
| description | Paraneoplastic neurologic syndromes (PNS) are a rare heterogeneous group of disorders associated with malignancy that can result in significant functional impairment. One syndrome in particular, paraneoplastic cerebellar degeneration (PCD), may be severely disabling. PCD is a rare neurological syndrome, associated with active or subclinical cancer, characterized by acute or subacute onset cerebellar ataxia due to tumor-induced autoimmunity against cerebellar antigens. Treatment of paraneoplastic syndromes is generally unsatisfactory, but early diagnosis and treatment of PCD, which includes neurological treatment, immunotherapy and oncological treatment of associated malignancy, may improve the neurological prognosis. We reported the case of a 59-year-old woman who presented PCD as the first sign of ovarian cancer. Laboratory investigations showed the presence of anti-Yo antibodies in the serum. The brain MRI revealed specific modifications for PCD. After oncological treatment, intravenous immunoglobulin therapy and corticosteroid therapy, the oncological response was satisfactory, but no improvement of the neurologic symptoms was achieved. |
| first_indexed | 2024-12-16T09:39:37Z |
| format | Article |
| id | doaj.art-9dd84ad59cb84ffabfefbab0a8a39f26 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-12-16T09:39:37Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-9dd84ad59cb84ffabfefbab0a8a39f262022-12-21T22:36:18ZengElsevierGynecologic Oncology Reports2352-57892021-02-0135100695Paraneoplastic cerebellar degeneration associated with anti-Yo antibodies in an ovarian cancer case: A case reportSandra Deac0Mihaela Marioara Stana1Andrei Dan Havasi2Calin Cainap3Anca-Raluca Popita4Ana Maria Bordeianu5Simona Cainap6Madalina Bota7Ovidiu Vasile Bochis8Oncology Institute “Ion Chiricuta”, Medical Oncology Department, Cluj Napoca, Romania; Corresponding author.Oncology Institute “Ion Chiricuta”, Medical Oncology Department, Cluj Napoca, RomaniaOncology Institute “Ion Chiricuta”, Medical Oncology Department, Cluj Napoca, RomaniaOncology Institute “Ion Chiricuta”, Medical Oncology Department, Cluj Napoca, Romania; Department of Oncology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj Napoca, RomaniaOncology Institute “Ion Chiricuta”, Radiology and Medical Imaging Department, Cluj Napoca, RomaniaRoNEURO Institute, Cluj-Napoca, RomaniaDepartment of Mother and Child, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj Napoca, RomaniaDepartment of Mother and Child, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj Napoca, RomaniaOncology Institute “Ion Chiricuta”, Medical Oncology Department, Cluj Napoca, RomaniaParaneoplastic neurologic syndromes (PNS) are a rare heterogeneous group of disorders associated with malignancy that can result in significant functional impairment. One syndrome in particular, paraneoplastic cerebellar degeneration (PCD), may be severely disabling. PCD is a rare neurological syndrome, associated with active or subclinical cancer, characterized by acute or subacute onset cerebellar ataxia due to tumor-induced autoimmunity against cerebellar antigens. Treatment of paraneoplastic syndromes is generally unsatisfactory, but early diagnosis and treatment of PCD, which includes neurological treatment, immunotherapy and oncological treatment of associated malignancy, may improve the neurological prognosis. We reported the case of a 59-year-old woman who presented PCD as the first sign of ovarian cancer. Laboratory investigations showed the presence of anti-Yo antibodies in the serum. The brain MRI revealed specific modifications for PCD. After oncological treatment, intravenous immunoglobulin therapy and corticosteroid therapy, the oncological response was satisfactory, but no improvement of the neurologic symptoms was achieved.http://www.sciencedirect.com/science/article/pii/S2352578920301612Paraneoplastic cerebellar degenerationParaneoplastic syndromesAnti-Yo antibodiesOvarian cancerGynecological cancer |
| spellingShingle | Sandra Deac Mihaela Marioara Stana Andrei Dan Havasi Calin Cainap Anca-Raluca Popita Ana Maria Bordeianu Simona Cainap Madalina Bota Ovidiu Vasile Bochis Paraneoplastic cerebellar degeneration associated with anti-Yo antibodies in an ovarian cancer case: A case report Gynecologic Oncology Reports Paraneoplastic cerebellar degeneration Paraneoplastic syndromes Anti-Yo antibodies Ovarian cancer Gynecological cancer |
| title | Paraneoplastic cerebellar degeneration associated with anti-Yo antibodies in an ovarian cancer case: A case report |
| title_full | Paraneoplastic cerebellar degeneration associated with anti-Yo antibodies in an ovarian cancer case: A case report |
| title_fullStr | Paraneoplastic cerebellar degeneration associated with anti-Yo antibodies in an ovarian cancer case: A case report |
| title_full_unstemmed | Paraneoplastic cerebellar degeneration associated with anti-Yo antibodies in an ovarian cancer case: A case report |
| title_short | Paraneoplastic cerebellar degeneration associated with anti-Yo antibodies in an ovarian cancer case: A case report |
| title_sort | paraneoplastic cerebellar degeneration associated with anti yo antibodies in an ovarian cancer case a case report |
| topic | Paraneoplastic cerebellar degeneration Paraneoplastic syndromes Anti-Yo antibodies Ovarian cancer Gynecological cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2352578920301612 |
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