Lipid Peroxidation and Antioxidant Status in Patients with Medullary Thyroid Carcinoma: A Case-Control Study
Introduction: Oxidative stress or oxidant/antioxidant imbalance has a crucial role in the pathogenesis of some diseases like cancer. Medullary thyroid carcinoma (MTC) originates in the thyroid parafollicular cells and includes 3-4% of the malignant neoplasms that have an effect on this gland. Th...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7202/17854_CE[Ra1]_F(AK)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Oxidative stress or oxidant/antioxidant imbalance
has a crucial role in the pathogenesis of some diseases like
cancer. Medullary thyroid carcinoma (MTC) originates in the
thyroid parafollicular cells and includes 3-4% of the malignant
neoplasms that have an effect on this gland. The aetiology of
MTC has not been clarified. However, oxidative stress may be
one of the factors involved.
Aim: The aim of the current study was to evaluate the
antioxidant enzyme activity of catalase (CAT), Glutathione
(GSH), total antioxidant capacity (TAC) and the levels of the lipid
peroxidation product malondialdehyde (MDA) in blood samples
of MTC patients as compared to healthy controls.
Materials and Methods: A case-control study was designed
enrolling patients with confirmed MTC diagnosis and age-and
sex group matched healthy volunteers referred to the clinic of
the Research Institute for Endocrine Sciences, Tehran, Iran from
April 2013 to July 2015. Fasting blood samples were taken for
study. Catalase, GSH, MDA and TAC levels were measured by
colorimetry using commercial kits (ZellBio GmbH, Germany).
Data were analysed using SPSS 17 software, comparing
mean±SD through t-test and difference between proportions
through chi-square.
Results: No statistical difference was observed in the
demographic characteristic between cases and controls. The
final MTC group included 40 males and 45 females with a mean
age of 30±12.9 year, and the control group 40 males and 47
females, with a mean age of 31.2±12.3 year. Anthropometric
parameters, dietary and thyroid hormones levels (T3, T4 and
TSH) were similar. Serum TAC (p=0.015), GSH (p=0.029) and
CAT (p<0.001) levels were found to be significantly lower in the
MTC patients, while serum MDA levels were significantly higher
in MTC patients than controls (p<0.001).
Conclusion: These preliminary findings suggest that oxidant/
antioxidant imbalance may be associated with or possibly
indicate an increased risk to medullary thyroid carcinoma.
Further studies are needed to explore these findings. |
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| ISSN: | 2249-782X 0973-709X |