Differential Genetic and Epigenetic Regulation of Catechol-O-Methyl-Transferase (COMT) is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder

Differential Genetic and Epigenetic Regulation of Catechol-O-Methyl-Transferase (COMT) is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder

The catechol-O-methyltransferase (COMT) enzyme is critical for the catabolic regulation of synaptic dopamine, resulting in altered cortical functioning. The COMT Val158Met polymorphism has been implicated in human mental illness, with Met/Met homozygotes associated with increased susceptibility to...

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Bibliographic Details
Main Authors: Seth Davin Norrholm, Tanja eJovanovic, Alicia eSmith, Elisabeth B Binder, Torsten eKlengel, Karen eConneely, Kristina B. Mercer, Jennifer S. Davis, Kimberly eKerley, Jennifer A. Winkler, Charles F. Gillespie, Bekh eBradley, Kerry J Ressler
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Methylation
posttraumatic stress disorder
epigenetic
Trauma
catechol-O-methyltransferase
fear-potentiated startle
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00030/full

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