Melatonin and Cancer Hallmarks
Melatonin is a natural indoleamine produced by the pineal gland that has many functions, including regulation of the circadian rhythm. Many studies have reported the anticancer effect of melatonin against a myriad of cancer types. Cancer hallmarks include sustained proliferation, evading growth supp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/3/518 |
| _version_ | 1811259373113049088 |
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| author | Wamidh H. Talib |
| author_facet | Wamidh H. Talib |
| author_sort | Wamidh H. Talib |
| collection | DOAJ |
| description | Melatonin is a natural indoleamine produced by the pineal gland that has many functions, including regulation of the circadian rhythm. Many studies have reported the anticancer effect of melatonin against a myriad of cancer types. Cancer hallmarks include sustained proliferation, evading growth suppressors, metastasis, replicative immortality, angiogenesis, resisting cell death, altered cellular energetics, and immune evasion. Melatonin anticancer activity is mediated by interfering with various cancer hallmarks. This review summarizes the anticancer role of melatonin in each cancer hallmark. The studies discussed in this review should serve as a solid foundation for researchers and physicians to support basic and clinical studies on melatonin as a promising anticancer agent. |
| first_indexed | 2024-04-12T18:29:17Z |
| format | Article |
| id | doaj.art-9ddbae4953564713bd9c1c63e8bf44c2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T18:29:17Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9ddbae4953564713bd9c1c63e8bf44c22022-12-22T03:21:08ZengMDPI AGMolecules1420-30492018-02-0123351810.3390/molecules23030518molecules23030518Melatonin and Cancer HallmarksWamidh H. Talib0Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931-166, JordanMelatonin is a natural indoleamine produced by the pineal gland that has many functions, including regulation of the circadian rhythm. Many studies have reported the anticancer effect of melatonin against a myriad of cancer types. Cancer hallmarks include sustained proliferation, evading growth suppressors, metastasis, replicative immortality, angiogenesis, resisting cell death, altered cellular energetics, and immune evasion. Melatonin anticancer activity is mediated by interfering with various cancer hallmarks. This review summarizes the anticancer role of melatonin in each cancer hallmark. The studies discussed in this review should serve as a solid foundation for researchers and physicians to support basic and clinical studies on melatonin as a promising anticancer agent.http://www.mdpi.com/1420-3049/23/3/518melatonincancer hallmarksanticancerangiogenesismetastasisimmune evasion |
| spellingShingle | Wamidh H. Talib Melatonin and Cancer Hallmarks Molecules melatonin cancer hallmarks anticancer angiogenesis metastasis immune evasion |
| title | Melatonin and Cancer Hallmarks |
| title_full | Melatonin and Cancer Hallmarks |
| title_fullStr | Melatonin and Cancer Hallmarks |
| title_full_unstemmed | Melatonin and Cancer Hallmarks |
| title_short | Melatonin and Cancer Hallmarks |
| title_sort | melatonin and cancer hallmarks |
| topic | melatonin cancer hallmarks anticancer angiogenesis metastasis immune evasion |
| url | http://www.mdpi.com/1420-3049/23/3/518 |
| work_keys_str_mv | AT wamidhhtalib melatoninandcancerhallmarks |