Reversal of splicing infidelity is a pre-activation step in B cell differentiation

Reversal of splicing infidelity is a pre-activation step in B cell differentiation

IntroductionB cell activation and differentiation is central to the adaptive immune response. Changes in exon usage can have major impacts on cellular signaling and differentiation but have not been systematically explored in differentiating B cells.MethodsWe analyzed exon usage and intron retention...

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Bibliographic Details
Main Authors: Tina M. O’Grady, Melody Baddoo, Samuel A. Flemington, Eman Y. Ishaq, Nathan A. Ungerleider, Erik K. Flemington
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
lymphocyte activation
mRNA
alternative splicing
exon skipping
naïve B cells
lymphoid tissue
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1060114/full

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