Physicochemical characteristics and anti-hyperlipidemic effect of polysaccharide from BaChu mushroom (Helvella leucopus)
To investigate the effects of Helvella leucopus (H. leucopus) on hyperlipidemic mice, polysaccharide (HLP) was prepared from H. leucopus by hot water extraction and alcohol precipitation. HLP was primarily contained glucose, rhamnose, galactose and mannose, with an average molecular weight of 7.34 ×...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Food Chemistry: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590157522002413 |
| _version_ | 1818028942696644608 |
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| author | Yazhong Ge Huamai Qiu Jianxian Zheng |
| author_facet | Yazhong Ge Huamai Qiu Jianxian Zheng |
| author_sort | Yazhong Ge |
| collection | DOAJ |
| description | To investigate the effects of Helvella leucopus (H. leucopus) on hyperlipidemic mice, polysaccharide (HLP) was prepared from H. leucopus by hot water extraction and alcohol precipitation. HLP was primarily contained glucose, rhamnose, galactose and mannose, with an average molecular weight of 7.34 × 104 Da. It was a complex and irregular network with a few pores by scanning electron microscopy. Meanwhile, oral administration of HLP at 60 mg/kg decreased levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol in serum while increased that of high-density lipoprotein cholesterol in high fat diet (HFD) mice. Furthermore, HLP significantly reversed the serum aspartate transaminase, alanine transaminase, and free fatty acid levels in HFD mice. Moreover, HLP treatment markedly regulated the mRNA levels of PPAR-α, ACS, and CPT-1α compared to the model group. Thus, these findings support that the supplement of Helvella leucopus polysaccharide is a novel complementary alternative strategy for management of hyperlipidemia. |
| first_indexed | 2024-12-10T05:11:49Z |
| format | Article |
| id | doaj.art-9ddce00b00e34cf5bd538ecebee55e38 |
| institution | Directory Open Access Journal |
| issn | 2590-1575 |
| language | English |
| last_indexed | 2024-12-10T05:11:49Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Chemistry: X |
| spelling | doaj.art-9ddce00b00e34cf5bd538ecebee55e382022-12-22T02:01:05ZengElsevierFood Chemistry: X2590-15752022-10-0115100443Physicochemical characteristics and anti-hyperlipidemic effect of polysaccharide from BaChu mushroom (Helvella leucopus)Yazhong Ge0Huamai Qiu1Jianxian Zheng2School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510640, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510640, ChinaCorresponding author.; School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510640, ChinaTo investigate the effects of Helvella leucopus (H. leucopus) on hyperlipidemic mice, polysaccharide (HLP) was prepared from H. leucopus by hot water extraction and alcohol precipitation. HLP was primarily contained glucose, rhamnose, galactose and mannose, with an average molecular weight of 7.34 × 104 Da. It was a complex and irregular network with a few pores by scanning electron microscopy. Meanwhile, oral administration of HLP at 60 mg/kg decreased levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol in serum while increased that of high-density lipoprotein cholesterol in high fat diet (HFD) mice. Furthermore, HLP significantly reversed the serum aspartate transaminase, alanine transaminase, and free fatty acid levels in HFD mice. Moreover, HLP treatment markedly regulated the mRNA levels of PPAR-α, ACS, and CPT-1α compared to the model group. Thus, these findings support that the supplement of Helvella leucopus polysaccharide is a novel complementary alternative strategy for management of hyperlipidemia.http://www.sciencedirect.com/science/article/pii/S2590157522002413Helvella leucopusPolysaccharideHyperlipidemiaTotal cholesterolPPAR-α |
| spellingShingle | Yazhong Ge Huamai Qiu Jianxian Zheng Physicochemical characteristics and anti-hyperlipidemic effect of polysaccharide from BaChu mushroom (Helvella leucopus) Food Chemistry: X Helvella leucopus Polysaccharide Hyperlipidemia Total cholesterol PPAR-α |
| title | Physicochemical characteristics and anti-hyperlipidemic effect of polysaccharide from BaChu mushroom (Helvella leucopus) |
| title_full | Physicochemical characteristics and anti-hyperlipidemic effect of polysaccharide from BaChu mushroom (Helvella leucopus) |
| title_fullStr | Physicochemical characteristics and anti-hyperlipidemic effect of polysaccharide from BaChu mushroom (Helvella leucopus) |
| title_full_unstemmed | Physicochemical characteristics and anti-hyperlipidemic effect of polysaccharide from BaChu mushroom (Helvella leucopus) |
| title_short | Physicochemical characteristics and anti-hyperlipidemic effect of polysaccharide from BaChu mushroom (Helvella leucopus) |
| title_sort | physicochemical characteristics and anti hyperlipidemic effect of polysaccharide from bachu mushroom helvella leucopus |
| topic | Helvella leucopus Polysaccharide Hyperlipidemia Total cholesterol PPAR-α |
| url | http://www.sciencedirect.com/science/article/pii/S2590157522002413 |
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