Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer
Abstract Purpose To examine the optimal timing of second ovarian stimulation using the dual stimulation method for good ovarian responders with cancer undergoing oocyte retrieval for fertility preservation. Methods A retrospective analysis was conducted using data from 69 patients with cancer who un...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Reproductive Medicine and Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rmb2.12534 |
| _version_ | 1797376227460251648 |
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| author | Hiroki Takeuchi Tadashi Maezawa Katsuyuki Hagiwara Yuki Horage Tetsuro Hanada Huang Haipeng Mito Sakamoto Mikiko Nishioka Erina Takayama Kento Terada Eiji Kondo Yasushi Takai Nao Suzuki Tomoaki Ikeda |
| author_facet | Hiroki Takeuchi Tadashi Maezawa Katsuyuki Hagiwara Yuki Horage Tetsuro Hanada Huang Haipeng Mito Sakamoto Mikiko Nishioka Erina Takayama Kento Terada Eiji Kondo Yasushi Takai Nao Suzuki Tomoaki Ikeda |
| author_sort | Hiroki Takeuchi |
| collection | DOAJ |
| description | Abstract Purpose To examine the optimal timing of second ovarian stimulation using the dual stimulation method for good ovarian responders with cancer undergoing oocyte retrieval for fertility preservation. Methods A retrospective analysis was conducted using data from 69 patients with cancer who underwent oocyte retrieval for fertility preservation at four Japanese institutions during 2010–2021. Twenty‐two patients underwent two oocyte retrievals for fertility preservation. We studied the relationship between the initial number of oocytes retrieved via dual stimulation and risk of ovarian enlargement as well as the appropriate waiting interval between the end of the first ovarian stimulation and beginning of the second ovarian stimulation. Results The risk of ovarian enlargement was high when the initial number of oocytes retrieved via dual stimulation was ≥5. An 8‐day waiting interval may be more effective for performing a second ovarian stimulation oocyte retrieval in these cases, although the difference was not significant. Conclusions This study provides one policy for effectively managing ovarian enlargement and timing of second ovarian stimulation during oocyte retrieval via the dual stimulation method for patients with cancer undergoing fertility preservation. If more facilities implement this procedure, more oocytes may be obtained in a short period for fertility preservation purposes. |
| first_indexed | 2024-03-08T19:35:34Z |
| format | Article |
| id | doaj.art-9ddd304c20bc46f094234daa056c987d |
| institution | Directory Open Access Journal |
| issn | 1445-5781 1447-0578 |
| language | English |
| last_indexed | 2024-03-08T19:35:34Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj.art-9ddd304c20bc46f094234daa056c987d2023-12-26T04:30:44ZengWileyReproductive Medicine and Biology1445-57811447-05782023-01-01221n/an/a10.1002/rmb2.12534Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancerHiroki Takeuchi0Tadashi Maezawa1Katsuyuki Hagiwara2Yuki Horage3Tetsuro Hanada4Huang Haipeng5Mito Sakamoto6Mikiko Nishioka7Erina Takayama8Kento Terada9Eiji Kondo10Yasushi Takai11Nao Suzuki12Tomoaki Ikeda13Department of Obstetrics and Gynecology, Graduate School of Medicine Mie University Tsu JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine Mie University Tsu JapanDepartment of Education Faculty, Graduate School Mie University Tsu JapanDepartment of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki JapanDepartment of Obstetrics and Gynecology Shiga University of Medical Science Otsu JapanDepartment of Obstetrics and Gynecology, Saitama Medical Center Saitama Medical University Kawagoe JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine Mie University Tsu JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine Mie University Tsu JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine Mie University Tsu JapanAdvanced Reproductive Medical Center Mie‐University Hospital Tsu JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine Mie University Tsu JapanDepartment of Obstetrics and Gynecology, Saitama Medical Center Saitama Medical University Kawagoe JapanDepartment of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki JapanDepartment of Obstetrics and Gynecology, Graduate School of Medicine Mie University Tsu JapanAbstract Purpose To examine the optimal timing of second ovarian stimulation using the dual stimulation method for good ovarian responders with cancer undergoing oocyte retrieval for fertility preservation. Methods A retrospective analysis was conducted using data from 69 patients with cancer who underwent oocyte retrieval for fertility preservation at four Japanese institutions during 2010–2021. Twenty‐two patients underwent two oocyte retrievals for fertility preservation. We studied the relationship between the initial number of oocytes retrieved via dual stimulation and risk of ovarian enlargement as well as the appropriate waiting interval between the end of the first ovarian stimulation and beginning of the second ovarian stimulation. Results The risk of ovarian enlargement was high when the initial number of oocytes retrieved via dual stimulation was ≥5. An 8‐day waiting interval may be more effective for performing a second ovarian stimulation oocyte retrieval in these cases, although the difference was not significant. Conclusions This study provides one policy for effectively managing ovarian enlargement and timing of second ovarian stimulation during oocyte retrieval via the dual stimulation method for patients with cancer undergoing fertility preservation. If more facilities implement this procedure, more oocytes may be obtained in a short period for fertility preservation purposes.https://doi.org/10.1002/rmb2.12534cryopreservationdual stimulationoncofertilitywaiting period |
| spellingShingle | Hiroki Takeuchi Tadashi Maezawa Katsuyuki Hagiwara Yuki Horage Tetsuro Hanada Huang Haipeng Mito Sakamoto Mikiko Nishioka Erina Takayama Kento Terada Eiji Kondo Yasushi Takai Nao Suzuki Tomoaki Ikeda Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer Reproductive Medicine and Biology cryopreservation dual stimulation oncofertility waiting period |
| title | Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer |
| title_full | Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer |
| title_fullStr | Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer |
| title_full_unstemmed | Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer |
| title_short | Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer |
| title_sort | investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer |
| topic | cryopreservation dual stimulation oncofertility waiting period |
| url | https://doi.org/10.1002/rmb2.12534 |
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