Affinity of anti-spike antibodies in SARS-CoV-2 patient plasma and its effect on COVID-19 antibody assays

Affinity of anti-spike antibodies in SARS-CoV-2 patient plasma and its effect on COVID-19 antibody assays

Summary: Background: Measuring anti-spike protein antibodies in human plasma or serum is commonly used to determine prior exposure to SARS-CoV-2 infection and to assess the anti-viral protection capacity. According to the mass-action law, a lesser concentration of tightly binding antibody can produ...

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Bibliographic Details
Main Authors: Patrick J. Macdonald, Qiaoqiao Ruan, Jessica L. Grieshaber, Kerry M. Swift, Russell E. Taylor, John C. Prostko, Sergey Y. Tetin
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:EBioMedicine
Subjects:
Antibody affinity
Immunoassays
HDIA
SARS-CoV-2 vaccination
Diagnostics
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421005909

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