Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at Childhood
The immune system in humans is regulated by the circadian rhythm. Published studies have reported that the time of vaccination is associated with the immune response to vaccine for some pathogens. Our study aimed to evaluate the association between time of dose administration of challenge HBV vaccin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/8/1326 |
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| author | Luca Coppeta Cristiana Ferrari Greta Verno Giuseppina Somma Marco Trabucco Aurilio Luca Di Giampaolo Michele Treglia Andrea Magrini Antonio Pietroiusti Stefano Rizza |
| author_facet | Luca Coppeta Cristiana Ferrari Greta Verno Giuseppina Somma Marco Trabucco Aurilio Luca Di Giampaolo Michele Treglia Andrea Magrini Antonio Pietroiusti Stefano Rizza |
| author_sort | Luca Coppeta |
| collection | DOAJ |
| description | The immune system in humans is regulated by the circadian rhythm. Published studies have reported that the time of vaccination is associated with the immune response to vaccine for some pathogens. Our study aimed to evaluate the association between time of dose administration of challenge HBV vaccine and seroconversion for anti-HBs in medical students vaccinated at birth who were found to be unprotected at pre-training screening. Humoral protection for HBV was assessed in 885 medical students vaccinated during childhood. In total, 359 (41.0%) of them showed anti-HBs titer < 10 UI/mL and received a challenge dose of HBV vaccine followed by post-vaccination screening 30–60 days later. The challenge dose elicited a protective immune response (anti-HBs IgG titer > 10 UI/mL) in 295 (83.8%) individuals. Seroconversion was significantly associated with female gender and time of vaccination after controlling for age group and nationality at logistic regression analysis. Students who received the booster dose in the morning had a higher response rate than those who received the vaccine in the afternoon (OR 1.93; 95% C.I. 1.047–3.56: <i>p</i> < 0.05). This finding suggests that morning administration of the HBV booster may result in a better immune response in susceptible individuals. |
| first_indexed | 2024-03-10T23:31:50Z |
| format | Article |
| id | doaj.art-9ddf7bb5e90244e48a0ab19515dd8d3c |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T23:31:50Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-9ddf7bb5e90244e48a0ab19515dd8d3c2023-11-19T03:17:32ZengMDPI AGVaccines2076-393X2023-08-01118132610.3390/vaccines11081326Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at ChildhoodLuca Coppeta0Cristiana Ferrari1Greta Verno2Giuseppina Somma3Marco Trabucco Aurilio4Luca Di Giampaolo5Michele Treglia6Andrea Magrini7Antonio Pietroiusti8Stefano Rizza9Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, ItalyDepartment of Occupational Medicine, University of Chieti “G. D’Annunzio”, 66100 Chieti, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyFaculty of Medicine, University “Nostra Signora del Buon Consiglio”, Tirana 1000, AlbaniaThe immune system in humans is regulated by the circadian rhythm. Published studies have reported that the time of vaccination is associated with the immune response to vaccine for some pathogens. Our study aimed to evaluate the association between time of dose administration of challenge HBV vaccine and seroconversion for anti-HBs in medical students vaccinated at birth who were found to be unprotected at pre-training screening. Humoral protection for HBV was assessed in 885 medical students vaccinated during childhood. In total, 359 (41.0%) of them showed anti-HBs titer < 10 UI/mL and received a challenge dose of HBV vaccine followed by post-vaccination screening 30–60 days later. The challenge dose elicited a protective immune response (anti-HBs IgG titer > 10 UI/mL) in 295 (83.8%) individuals. Seroconversion was significantly associated with female gender and time of vaccination after controlling for age group and nationality at logistic regression analysis. Students who received the booster dose in the morning had a higher response rate than those who received the vaccine in the afternoon (OR 1.93; 95% C.I. 1.047–3.56: <i>p</i> < 0.05). This finding suggests that morning administration of the HBV booster may result in a better immune response in susceptible individuals.https://www.mdpi.com/2076-393X/11/8/1326HBVvaccinationbooster dosemedical studentscircadian rhythmimmunological memory |
| spellingShingle | Luca Coppeta Cristiana Ferrari Greta Verno Giuseppina Somma Marco Trabucco Aurilio Luca Di Giampaolo Michele Treglia Andrea Magrini Antonio Pietroiusti Stefano Rizza Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at Childhood Vaccines HBV vaccination booster dose medical students circadian rhythm immunological memory |
| title | Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at Childhood |
| title_full | Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at Childhood |
| title_fullStr | Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at Childhood |
| title_full_unstemmed | Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at Childhood |
| title_short | Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at Childhood |
| title_sort | protective anti hbs antibodies and response to a booster dose in medical students vaccinated at childhood |
| topic | HBV vaccination booster dose medical students circadian rhythm immunological memory |
| url | https://www.mdpi.com/2076-393X/11/8/1326 |
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