Circulating Exosomal miRNAs as Biomarkers in Epithelial Ovarian Cancer
Failure to detect early-stage epithelial ovarian cancer (EOC) is a major contributing factor to its low survival rate. Increasing evidence suggests that different subtypes of EOC may behave as distinct diseases due to their different cells of origins, histology and treatment responses. Therefore, th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/10/1433 |
| _version_ | 1797515232998850560 |
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| author | Meng-Shin Shiao Jia-Ming Chang Arb-Aroon Lertkhachonsuk Naparat Rermluk Natini Jinawath |
| author_facet | Meng-Shin Shiao Jia-Ming Chang Arb-Aroon Lertkhachonsuk Naparat Rermluk Natini Jinawath |
| author_sort | Meng-Shin Shiao |
| collection | DOAJ |
| description | Failure to detect early-stage epithelial ovarian cancer (EOC) is a major contributing factor to its low survival rate. Increasing evidence suggests that different subtypes of EOC may behave as distinct diseases due to their different cells of origins, histology and treatment responses. Therefore, the identification of EOC subtype-specific biomarkers that can early detect the disease should be clinically beneficial. Exosomes are extracellular vesicles secreted by different types of cells and carry biological molecules, which play important roles in cell-cell communication and regulation of various biological processes. Multiple studies have proposed that exosomal miRNAs present in the circulation are good biomarkers for non-invasive early detection of cancer. In this review, the potential use of exosomal miRNAs as early detection biomarkers for EOCs and their accuracy are discussed. We also review the differential expression of circulating exosomal miRNAs and cell-free miRNAs between different biofluid sources, i.e., plasma and serum, and touch on the issue of endogenous reference miRNA selection. Additionally, the current clinical trials using miRNAs for detecting EOCs are summarized. In conclusion, circulating exosomal miRNAs as the non-invasive biomarkers have a high potential for early detection of EOC and its subtypes, and are likely to be clinically important in the future. |
| first_indexed | 2024-03-10T06:42:37Z |
| format | Article |
| id | doaj.art-9ddf9033000f44478a87e12af33e0422 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T06:42:37Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-9ddf9033000f44478a87e12af33e04222023-11-22T17:31:50ZengMDPI AGBiomedicines2227-90592021-10-01910143310.3390/biomedicines9101433Circulating Exosomal miRNAs as Biomarkers in Epithelial Ovarian CancerMeng-Shin Shiao0Jia-Ming Chang1Arb-Aroon Lertkhachonsuk2Naparat Rermluk3Natini Jinawath4Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Computer Science, National Chengchi University, Taipei 11605, TaiwanDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandRamathibodi Comprehensive Cancer Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandFailure to detect early-stage epithelial ovarian cancer (EOC) is a major contributing factor to its low survival rate. Increasing evidence suggests that different subtypes of EOC may behave as distinct diseases due to their different cells of origins, histology and treatment responses. Therefore, the identification of EOC subtype-specific biomarkers that can early detect the disease should be clinically beneficial. Exosomes are extracellular vesicles secreted by different types of cells and carry biological molecules, which play important roles in cell-cell communication and regulation of various biological processes. Multiple studies have proposed that exosomal miRNAs present in the circulation are good biomarkers for non-invasive early detection of cancer. In this review, the potential use of exosomal miRNAs as early detection biomarkers for EOCs and their accuracy are discussed. We also review the differential expression of circulating exosomal miRNAs and cell-free miRNAs between different biofluid sources, i.e., plasma and serum, and touch on the issue of endogenous reference miRNA selection. Additionally, the current clinical trials using miRNAs for detecting EOCs are summarized. In conclusion, circulating exosomal miRNAs as the non-invasive biomarkers have a high potential for early detection of EOC and its subtypes, and are likely to be clinically important in the future.https://www.mdpi.com/2227-9059/9/10/1433exosomemiRNAbiomarkersepithelial ovarian cancerliquid biopsy |
| spellingShingle | Meng-Shin Shiao Jia-Ming Chang Arb-Aroon Lertkhachonsuk Naparat Rermluk Natini Jinawath Circulating Exosomal miRNAs as Biomarkers in Epithelial Ovarian Cancer Biomedicines exosome miRNA biomarkers epithelial ovarian cancer liquid biopsy |
| title | Circulating Exosomal miRNAs as Biomarkers in Epithelial Ovarian Cancer |
| title_full | Circulating Exosomal miRNAs as Biomarkers in Epithelial Ovarian Cancer |
| title_fullStr | Circulating Exosomal miRNAs as Biomarkers in Epithelial Ovarian Cancer |
| title_full_unstemmed | Circulating Exosomal miRNAs as Biomarkers in Epithelial Ovarian Cancer |
| title_short | Circulating Exosomal miRNAs as Biomarkers in Epithelial Ovarian Cancer |
| title_sort | circulating exosomal mirnas as biomarkers in epithelial ovarian cancer |
| topic | exosome miRNA biomarkers epithelial ovarian cancer liquid biopsy |
| url | https://www.mdpi.com/2227-9059/9/10/1433 |
| work_keys_str_mv | AT mengshinshiao circulatingexosomalmirnasasbiomarkersinepithelialovariancancer AT jiamingchang circulatingexosomalmirnasasbiomarkersinepithelialovariancancer AT arbaroonlertkhachonsuk circulatingexosomalmirnasasbiomarkersinepithelialovariancancer AT naparatrermluk circulatingexosomalmirnasasbiomarkersinepithelialovariancancer AT natinijinawath circulatingexosomalmirnasasbiomarkersinepithelialovariancancer |