Association of urinary nickel levels with diabetes and fasting blood glucose levels: A nationwide Chinese population-based study
Some epidemiological studies support a relationship between nickel exposure and diabetes in the general population. To address this, we tested the association of nickel exposure with diabetes in 10,890 adults aged ≥ 18 years old from the China National Human Biomonitoring study conducted in 2017–201...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323001057 |
| _version_ | 1797903044251222016 |
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| author | Yingli Qu Saisai Ji Qi Sun Feng Zhao Zheng Li Miao Zhang Yawei Li Lei Zheng Haocan Song Wenli Zhang Heng Gu Hui Fu Xulin Zheng Jiayi Cai Ying Zhu Zhaojin Cao Yuebin Lv Xiaoming Shi |
| author_facet | Yingli Qu Saisai Ji Qi Sun Feng Zhao Zheng Li Miao Zhang Yawei Li Lei Zheng Haocan Song Wenli Zhang Heng Gu Hui Fu Xulin Zheng Jiayi Cai Ying Zhu Zhaojin Cao Yuebin Lv Xiaoming Shi |
| author_sort | Yingli Qu |
| collection | DOAJ |
| description | Some epidemiological studies support a relationship between nickel exposure and diabetes in the general population. To address this, we tested the association of nickel exposure with diabetes in 10,890 adults aged ≥ 18 years old from the China National Human Biomonitoring study conducted in 2017–2018. Urinary nickel concentrations and fasting blood glucose (FBG) were measured, and lifestyle and demographic data were collected. Weighted logistic and linear regressions were used to estimate the associations of urinary nickel levels with diabetes prevalence and FBG. Restricted cubic splines (RCS) were used to test for the dose-response relationship. The odd ratio (95% confidence interval [CI]) of diabetes for the highest versus lowest quartiles of urinary nickel concentrations was 1.74 (1.28, 2.36) in the multivariate model (p trend =0.001). Each one-unit increase in log-transformed urinary nickel concentrations was associated with a 0.36 (0.17, 0.55) mmol/L elevation in FBG. The RCS curves showed a monotonically increasing dose-response relationship of urinary nickel with diabetes as well as FBG levels, and then tended to flatten after about 4.75 μg/L of nickel exposure. The nickel-diabetes association was stronger in individuals with lower than those with higher rice consumption (OR: 2.39 vs. 1.72). Our study supports a positive association between nickel exposure and diabetes prevalence in Chinese adults, especially in individuals with lower rice consumption. Further large-scale prospective studies are needed to validate our findings. |
| first_indexed | 2024-04-10T09:25:41Z |
| format | Article |
| id | doaj.art-9de1fee48de0460b9614b589f4ede3fa |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-10T09:25:41Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-9de1fee48de0460b9614b589f4ede3fa2023-02-20T04:08:39ZengElsevierEcotoxicology and Environmental Safety0147-65132023-03-01252114601Association of urinary nickel levels with diabetes and fasting blood glucose levels: A nationwide Chinese population-based studyYingli Qu0Saisai Ji1Qi Sun2Feng Zhao3Zheng Li4Miao Zhang5Yawei Li6Lei Zheng7Haocan Song8Wenli Zhang9Heng Gu10Hui Fu11Xulin Zheng12Jiayi Cai13Ying Zhu14Zhaojin Cao15Yuebin Lv16Xiaoming Shi17China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaCorrespondence to: National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Chaoyang, Beijing 100021, ChinaSome epidemiological studies support a relationship between nickel exposure and diabetes in the general population. To address this, we tested the association of nickel exposure with diabetes in 10,890 adults aged ≥ 18 years old from the China National Human Biomonitoring study conducted in 2017–2018. Urinary nickel concentrations and fasting blood glucose (FBG) were measured, and lifestyle and demographic data were collected. Weighted logistic and linear regressions were used to estimate the associations of urinary nickel levels with diabetes prevalence and FBG. Restricted cubic splines (RCS) were used to test for the dose-response relationship. The odd ratio (95% confidence interval [CI]) of diabetes for the highest versus lowest quartiles of urinary nickel concentrations was 1.74 (1.28, 2.36) in the multivariate model (p trend =0.001). Each one-unit increase in log-transformed urinary nickel concentrations was associated with a 0.36 (0.17, 0.55) mmol/L elevation in FBG. The RCS curves showed a monotonically increasing dose-response relationship of urinary nickel with diabetes as well as FBG levels, and then tended to flatten after about 4.75 μg/L of nickel exposure. The nickel-diabetes association was stronger in individuals with lower than those with higher rice consumption (OR: 2.39 vs. 1.72). Our study supports a positive association between nickel exposure and diabetes prevalence in Chinese adults, especially in individuals with lower rice consumption. Further large-scale prospective studies are needed to validate our findings.http://www.sciencedirect.com/science/article/pii/S0147651323001057DiabetesFasting blood glucoseUrinary nickel levelsChina National Human Biomonitoring |
| spellingShingle | Yingli Qu Saisai Ji Qi Sun Feng Zhao Zheng Li Miao Zhang Yawei Li Lei Zheng Haocan Song Wenli Zhang Heng Gu Hui Fu Xulin Zheng Jiayi Cai Ying Zhu Zhaojin Cao Yuebin Lv Xiaoming Shi Association of urinary nickel levels with diabetes and fasting blood glucose levels: A nationwide Chinese population-based study Ecotoxicology and Environmental Safety Diabetes Fasting blood glucose Urinary nickel levels China National Human Biomonitoring |
| title | Association of urinary nickel levels with diabetes and fasting blood glucose levels: A nationwide Chinese population-based study |
| title_full | Association of urinary nickel levels with diabetes and fasting blood glucose levels: A nationwide Chinese population-based study |
| title_fullStr | Association of urinary nickel levels with diabetes and fasting blood glucose levels: A nationwide Chinese population-based study |
| title_full_unstemmed | Association of urinary nickel levels with diabetes and fasting blood glucose levels: A nationwide Chinese population-based study |
| title_short | Association of urinary nickel levels with diabetes and fasting blood glucose levels: A nationwide Chinese population-based study |
| title_sort | association of urinary nickel levels with diabetes and fasting blood glucose levels a nationwide chinese population based study |
| topic | Diabetes Fasting blood glucose Urinary nickel levels China National Human Biomonitoring |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323001057 |
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