Discovery and engineering of a novel peptide, Temporin-WY2, with enhanced in vitro and in vivo efficacy against multi-drug resistant bacteria

Abstract Infections by drug-resistant microorganisms are a threat to global health and antimicrobial peptides are considered to be a new hope for their treatment. Temporin-WY2 was identified from the cutaneous secretion of the Ranidae frog, Amolops wuyiensis. It presented with a potent anti-Gram-pos...

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Bibliographic Details
Main Authors: Fengting Liao, Zhuming Ye, Jinsheng Cheng, Jianhua Zhu, Xiaoling Chen, Xiaowei Zhou, Tao Wang, Yangyang Jiang, Chengbang Ma, Mei Zhou, Tianbao Chen, Chris Shaw, Lei Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-67777-1