Age, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PET
Brain cannabinoid 1 receptors (CB1Rs) contribute importantly to the regulation of autonomic tone, appetite, mood and cognition. Inconsistent results have been reported from positron emission tomography (PET) studies using different radioligands to examine relationships between age, gender and body m...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922007959 |
| _version_ | 1811178735005597696 |
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| author | Rajiv Radhakrishnan Patrick D. Worhunsky Ming-Qiang Zheng Soheila Najafzadeh Jean-Dominique Gallezot Beata Planeta Shannan Henry Nabeel Nabulsi Mohini Ranganathan Patrick D. Skosnik Brian Pittman Deepak Cyril D'Souza Richard E. Carson Yiyun Huang Marc N. Potenza David Matuskey |
| author_facet | Rajiv Radhakrishnan Patrick D. Worhunsky Ming-Qiang Zheng Soheila Najafzadeh Jean-Dominique Gallezot Beata Planeta Shannan Henry Nabeel Nabulsi Mohini Ranganathan Patrick D. Skosnik Brian Pittman Deepak Cyril D'Souza Richard E. Carson Yiyun Huang Marc N. Potenza David Matuskey |
| author_sort | Rajiv Radhakrishnan |
| collection | DOAJ |
| description | Brain cannabinoid 1 receptors (CB1Rs) contribute importantly to the regulation of autonomic tone, appetite, mood and cognition. Inconsistent results have been reported from positron emission tomography (PET) studies using different radioligands to examine relationships between age, gender and body mass index (BMI) and CB1R availability in healthy individuals. In this study, we examined these variables in 58 healthy individuals (age range: 18–55 years; 44 male; BMI=27.01±5.56), the largest cohort of subjects studied to date using the CB1R PET ligand [11C]OMAR. There was a significant decline in CB1R availability (VT) with age in the pallidum, cerebellum and posterior cingulate. Adjusting for BMI, age-related decline in VT remained significant in the posterior cingulate among males, and in the cerebellum among women. CB1R availability was higher in women compared to men in the thalamus, pallidum and posterior cingulate. Adjusting for age, CB1R availability negatively correlated with BMI in women but not men. These findings differ from those reported using [11C]OMAR and other radioligands such as [18F]FMPEP-d2 and [18F]MK-9470. Although reasons for these seemingly divergent findings are unclear, the choice of PET radioligand and range of BMI in the current dataset may contribute to the observed differences. This study highlights the need for cross-validation studies using both [11C]OMAR and [18F]FMPEP-d2 within the same cohort of subjects. |
| first_indexed | 2024-04-11T06:24:22Z |
| format | Article |
| id | doaj.art-9de586064209481782f15b47c783091f |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-11T06:24:22Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-9de586064209481782f15b47c783091f2022-12-22T04:40:27ZengElsevierNeuroImage1095-95722022-12-01264119674Age, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PETRajiv Radhakrishnan0Patrick D. Worhunsky1Ming-Qiang Zheng2Soheila Najafzadeh3Jean-Dominique Gallezot4Beata Planeta5Shannan Henry6Nabeel Nabulsi7Mohini Ranganathan8Patrick D. Skosnik9Brian Pittman10Deepak Cyril D'Souza11Richard E. Carson12Yiyun Huang13Marc N. Potenza14David Matuskey15Department of Psychiatry, Yale University School of Medicinev, New Haven, CT 06511, United States; Corresponding author.Department of Psychiatry, Yale University School of Medicinev, New Haven, CT 06511, United StatesDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, United StatesDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, United StatesDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, United StatesDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, United StatesDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, United StatesDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, United StatesDepartment of Psychiatry, Yale University School of Medicinev, New Haven, CT 06511, United StatesDepartment of Psychiatry, Yale University School of Medicinev, New Haven, CT 06511, United StatesDepartment of Psychiatry, Yale University School of Medicinev, New Haven, CT 06511, United StatesDepartment of Psychiatry, Yale University School of Medicinev, New Haven, CT 06511, United StatesDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, United StatesDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, United StatesDepartment of Psychiatry, Yale University School of Medicinev, New Haven, CT 06511, United States; Child Study Center, Yale University School of Medicine, United States; Connecticut Mental Health Center, United States; Department of Neuroscience, Yale University, United StatesDepartment of Psychiatry, Yale University School of Medicinev, New Haven, CT 06511, United States; Department of Radiology and Biomedical Imaging, Yale University School of Medicine, United States; Department of Neurology, Yale University School of Medicine, United StatesBrain cannabinoid 1 receptors (CB1Rs) contribute importantly to the regulation of autonomic tone, appetite, mood and cognition. Inconsistent results have been reported from positron emission tomography (PET) studies using different radioligands to examine relationships between age, gender and body mass index (BMI) and CB1R availability in healthy individuals. In this study, we examined these variables in 58 healthy individuals (age range: 18–55 years; 44 male; BMI=27.01±5.56), the largest cohort of subjects studied to date using the CB1R PET ligand [11C]OMAR. There was a significant decline in CB1R availability (VT) with age in the pallidum, cerebellum and posterior cingulate. Adjusting for BMI, age-related decline in VT remained significant in the posterior cingulate among males, and in the cerebellum among women. CB1R availability was higher in women compared to men in the thalamus, pallidum and posterior cingulate. Adjusting for age, CB1R availability negatively correlated with BMI in women but not men. These findings differ from those reported using [11C]OMAR and other radioligands such as [18F]FMPEP-d2 and [18F]MK-9470. Although reasons for these seemingly divergent findings are unclear, the choice of PET radioligand and range of BMI in the current dataset may contribute to the observed differences. This study highlights the need for cross-validation studies using both [11C]OMAR and [18F]FMPEP-d2 within the same cohort of subjects.http://www.sciencedirect.com/science/article/pii/S1053811922007959Cannabinoid 1 receptor[11C]OMARAge effectGender effectBody-mass indexHealthy humans |
| spellingShingle | Rajiv Radhakrishnan Patrick D. Worhunsky Ming-Qiang Zheng Soheila Najafzadeh Jean-Dominique Gallezot Beata Planeta Shannan Henry Nabeel Nabulsi Mohini Ranganathan Patrick D. Skosnik Brian Pittman Deepak Cyril D'Souza Richard E. Carson Yiyun Huang Marc N. Potenza David Matuskey Age, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PET NeuroImage Cannabinoid 1 receptor [11C]OMAR Age effect Gender effect Body-mass index Healthy humans |
| title | Age, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PET |
| title_full | Age, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PET |
| title_fullStr | Age, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PET |
| title_full_unstemmed | Age, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PET |
| title_short | Age, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PET |
| title_sort | age gender and body mass index relationships with in vivo cb1 receptor availability in healthy humans measured with 11c omar pet |
| topic | Cannabinoid 1 receptor [11C]OMAR Age effect Gender effect Body-mass index Healthy humans |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922007959 |
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