Gastrointestinal Biopsy in Henoch-Schönlein Purpura: A Great Diagnostic Contribution
Henoch-Schönlein purpura is an IgA-mediated immune vasculitis which is characterized by purpuric lesions and osteoarticular, intestinal and sometimes renal manifestations. The histopathological substrate of this entity is leucocytoclastic vasculitis (LCV) with IgA deposits seen on immunohistochemist...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2017-09-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | http://www.ejcrim.com/index.php/EJCRIM/article/view/662 |
| _version_ | 1819054368983351296 |
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| author | Imen Akkari Soumaya Mrabet Elhem Ben Jazia |
| author_facet | Imen Akkari Soumaya Mrabet Elhem Ben Jazia |
| author_sort | Imen Akkari |
| collection | DOAJ |
| description | Henoch-Schönlein purpura is an IgA-mediated immune vasculitis which is characterized by purpuric lesions and osteoarticular, intestinal and sometimes renal manifestations. The histopathological substrate of this entity is leucocytoclastic vasculitis (LCV) with IgA deposits seen on immunohistochemistry. We here report the case of a 27-year-old woman with abdominal pain and cutaneous purpura. Upper and lower endoscopic exploration showed purpuric lesions in the rectum but not in the stomach. Skin biopsy revealed LCV. IgA deposits were seen only in gastric mucosa. The patient was treated with corticoids which led to improvement of both the cutaneous and digestive symptoms. This case suggests that gastrointestinal biopsies of both normal and abnormal mucosa should be taken in Henoch-Schönlein purpura, especially in patients with atypical forms. |
| first_indexed | 2024-12-21T12:50:31Z |
| format | Article |
| id | doaj.art-9de5eea714004e8cb040e5a0e2f3dc0f |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-12-21T12:50:31Z |
| publishDate | 2017-09-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-9de5eea714004e8cb040e5a0e2f3dc0f2022-12-21T19:03:30ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942017-09-012010.12890/2017_000662241Gastrointestinal Biopsy in Henoch-Schönlein Purpura: A Great Diagnostic ContributionImen Akkari0Soumaya Mrabet1Elhem Ben Jazia2Gastroenterology department, Farhat Hached Hospital, SousseGastroenterology department, Farhat Hached Hospital, SousseGastroenterology department, Farhat Hached Hospital, SousseHenoch-Schönlein purpura is an IgA-mediated immune vasculitis which is characterized by purpuric lesions and osteoarticular, intestinal and sometimes renal manifestations. The histopathological substrate of this entity is leucocytoclastic vasculitis (LCV) with IgA deposits seen on immunohistochemistry. We here report the case of a 27-year-old woman with abdominal pain and cutaneous purpura. Upper and lower endoscopic exploration showed purpuric lesions in the rectum but not in the stomach. Skin biopsy revealed LCV. IgA deposits were seen only in gastric mucosa. The patient was treated with corticoids which led to improvement of both the cutaneous and digestive symptoms. This case suggests that gastrointestinal biopsies of both normal and abnormal mucosa should be taken in Henoch-Schönlein purpura, especially in patients with atypical forms.http://www.ejcrim.com/index.php/EJCRIM/article/view/662Henoch–Schönlein purpura, gastrointestinal disease, endoscopy |
| spellingShingle | Imen Akkari Soumaya Mrabet Elhem Ben Jazia Gastrointestinal Biopsy in Henoch-Schönlein Purpura: A Great Diagnostic Contribution European Journal of Case Reports in Internal Medicine Henoch–Schönlein purpura, gastrointestinal disease, endoscopy |
| title | Gastrointestinal Biopsy in Henoch-Schönlein Purpura: A Great Diagnostic Contribution |
| title_full | Gastrointestinal Biopsy in Henoch-Schönlein Purpura: A Great Diagnostic Contribution |
| title_fullStr | Gastrointestinal Biopsy in Henoch-Schönlein Purpura: A Great Diagnostic Contribution |
| title_full_unstemmed | Gastrointestinal Biopsy in Henoch-Schönlein Purpura: A Great Diagnostic Contribution |
| title_short | Gastrointestinal Biopsy in Henoch-Schönlein Purpura: A Great Diagnostic Contribution |
| title_sort | gastrointestinal biopsy in henoch schonlein purpura a great diagnostic contribution |
| topic | Henoch–Schönlein purpura, gastrointestinal disease, endoscopy |
| url | http://www.ejcrim.com/index.php/EJCRIM/article/view/662 |
| work_keys_str_mv | AT imenakkari gastrointestinalbiopsyinhenochschonleinpurpuraagreatdiagnosticcontribution AT soumayamrabet gastrointestinalbiopsyinhenochschonleinpurpuraagreatdiagnosticcontribution AT elhembenjazia gastrointestinalbiopsyinhenochschonleinpurpuraagreatdiagnosticcontribution |