Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor.

Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor.

Histone deacetylase inhibitors (HDACis) re-express silenced tumor suppressor genes and are currently undergoing clinical trials. Although HDACis have been known to induce gene expression, an equal number of genes are downregulated upon HDAC inhibition. The mechanism behind this downregulation remain...

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Bibliographic Details
Main Authors: Sushant K Kachhap, Nadine Rosmus, Spencer J Collis, Madeleine S Q Kortenhorst, Michel D Wissing, Mohammad Hedayati, Shabana Shabbeer, Janet Mendonca, Justin Deangelis, Luigi Marchionni, Jianqing Lin, Naseruddin Höti, Johan W R Nortier, Theodore L DeWeese, Hans Hammers, Michael A Carducci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2887841?pdf=render

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