High baseline expression of IL-6 and IL-10 decreased CCR7 B cells in individuals with previous SARS-CoV-2 infection during BNT162b2 vaccination
The current pandemic generated by SARS-CoV-2 has led to mass vaccination with different biologics that have shown wide variations among human populations according to the origin and formulation of the vaccine. Studies evaluating the response in individuals with a natural infection before vaccination...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.946770/full |
| _version_ | 1811321286490587136 |
|---|---|
| author | Alberto Ponciano-Gómez Martha Iris Valle-Solis Myriam Campos-Aguilar Rafael Jijón-Lorenzo Elena de la C. Herrera-Cogco Roberto Ramos-Alor César Isaac Bazán-Mendez Gustavo Antonio Pérez-Gil Cervantes Ricardo Ávila-García Abdiel González Aguilar Moises Geovani Salmerón Texale Wilfrido David Tapia-Sánchez Carlos Leonardo Duarte-Martínez Sandra Olivas-Quintero Santiago Cristobal Sigrist-Flores Itzell Alejandrina Gallardo-Ortíz Rafael Villalobos-Molina Adolfo Rene Méndez-Cruz Rafael Jimenez-Flores Leopoldo Santos-Argumedo Juan Pedro Luna-Arias Hector Romero-Ramírez Victor Hugo Rosales-García Victor Hugo Rosales-García Bartolo Avendaño-Borromeo |
| author_facet | Alberto Ponciano-Gómez Martha Iris Valle-Solis Myriam Campos-Aguilar Rafael Jijón-Lorenzo Elena de la C. Herrera-Cogco Roberto Ramos-Alor César Isaac Bazán-Mendez Gustavo Antonio Pérez-Gil Cervantes Ricardo Ávila-García Abdiel González Aguilar Moises Geovani Salmerón Texale Wilfrido David Tapia-Sánchez Carlos Leonardo Duarte-Martínez Sandra Olivas-Quintero Santiago Cristobal Sigrist-Flores Itzell Alejandrina Gallardo-Ortíz Rafael Villalobos-Molina Adolfo Rene Méndez-Cruz Rafael Jimenez-Flores Leopoldo Santos-Argumedo Juan Pedro Luna-Arias Hector Romero-Ramírez Victor Hugo Rosales-García Victor Hugo Rosales-García Bartolo Avendaño-Borromeo |
| author_sort | Alberto Ponciano-Gómez |
| collection | DOAJ |
| description | The current pandemic generated by SARS-CoV-2 has led to mass vaccination with different biologics that have shown wide variations among human populations according to the origin and formulation of the vaccine. Studies evaluating the response in individuals with a natural infection before vaccination have been limited to antibody titer analysis and evaluating a few humoral and cellular response markers, showing a more rapid and intense humoral response than individuals without prior infection. However, the basis of these differences has not been explored in depth. In the present work, we analyzed a group of pro and anti-inflammatory cytokines, antibody titers, and cell populations in peripheral blood of individuals with previous SARS-CoV-2 infection using BNT162b2 biologic. Our results suggest that higher antibody concentration in individuals with an earlier disease could be generated by higher production of plasma cells to the detriment of the presence of memory B cells in the bloodstream, which could be related to the high baseline expression of cytokines (IL-6 and IL-10) before vaccination. |
| first_indexed | 2024-04-13T13:14:13Z |
| format | Article |
| id | doaj.art-9de834a23e8b470ebe5dd071217e9be3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T13:14:13Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9de834a23e8b470ebe5dd071217e9be32022-12-22T02:45:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.946770946770High baseline expression of IL-6 and IL-10 decreased CCR7 B cells in individuals with previous SARS-CoV-2 infection during BNT162b2 vaccinationAlberto Ponciano-Gómez0Martha Iris Valle-Solis1Myriam Campos-Aguilar2Rafael Jijón-Lorenzo3Elena de la C. Herrera-Cogco4Roberto Ramos-Alor5César Isaac Bazán-Mendez6Gustavo Antonio Pérez-Gil Cervantes7Ricardo Ávila-García8Abdiel González Aguilar9Moises Geovani Salmerón Texale10Wilfrido David Tapia-Sánchez11Carlos Leonardo Duarte-Martínez12Sandra Olivas-Quintero13Santiago Cristobal Sigrist-Flores14Itzell Alejandrina Gallardo-Ortíz15Rafael Villalobos-Molina16Adolfo Rene Méndez-Cruz17Rafael Jimenez-Flores18Leopoldo Santos-Argumedo19Juan Pedro Luna-Arias20Hector Romero-Ramírez21Victor Hugo Rosales-García22Victor Hugo Rosales-García23Bartolo Avendaño-Borromeo24Laboratorio de Inmunología, Unidad de Morfología y Función, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Estado de México, MexicoSecretaría de Salud de Veracruz, Servicios de Salud de Veracruz, SESVER, Xalapa Veracruz, MexicoLaboratorio de Inmunología, Unidad de Morfología y Función, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Estado de México, MexicoSecretaría de Salud de Veracruz, Servicios de Salud de Veracruz, SESVER, Xalapa Veracruz, MexicoSecretaría de Salud de Veracruz, Servicios de Salud de Veracruz, SESVER, Xalapa Veracruz, MexicoSecretaría de Salud de Veracruz, Servicios de Salud de Veracruz, SESVER, Xalapa Veracruz, MexicoLaboratorio Estatal de Salud Pública, Gobierno del Estado de Veracruz, Veracruz, MexicoSecretaría de Salud de Veracruz, Servicios de Salud de Veracruz, SESVER, Xalapa Veracruz, MexicoSecretaría de Salud de Veracruz, Servicios de Salud de Veracruz, SESVER, Xalapa Veracruz, MexicoSecretaría de Salud de Veracruz, Servicios de Salud de Veracruz, SESVER, Xalapa Veracruz, MexicoSecretaría de Salud de Veracruz, Servicios de Salud de Veracruz, SESVER, Xalapa Veracruz, MexicoLaboratorio de Citometría de Flujo y Hematología, Diagnóstico Molecular de Leucemias y Terapia Celular (DILETEC), Gustavo A. Madero, Ciudad de Mexico, MexicoLaboratorio de Citometría de Flujo y Hematología, Diagnóstico Molecular de Leucemias y Terapia Celular (DILETEC), Gustavo A. Madero, Ciudad de Mexico, MexicoDepartment of Health Sciences, Autonomus University of Occident, Culiacan, Sinaloa, MexicoLaboratorio de Inmunología, Unidad de Morfología y Función, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Estado de México, MexicoUnidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Estado de México, MexicoUnidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Estado de México, MexicoLaboratorio de Inmunología, Unidad de Morfología y Función, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Estado de México, MexicoLaboratorio de Inmunología, Unidad de Morfología y Función, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Estado de México, MexicoDepartamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de México, MexicoDepartamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de México, MexicoDepartamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de México, MexicoLaboratorio de Citometría de Flujo y Hematología, Diagnóstico Molecular de Leucemias y Terapia Celular (DILETEC), Gustavo A. Madero, Ciudad de Mexico, MexicoLaboratorios Nacionales de Servicios Experimentales, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, MexicoSecretaría de Salud de Veracruz, Servicios de Salud de Veracruz, SESVER, Xalapa Veracruz, MexicoThe current pandemic generated by SARS-CoV-2 has led to mass vaccination with different biologics that have shown wide variations among human populations according to the origin and formulation of the vaccine. Studies evaluating the response in individuals with a natural infection before vaccination have been limited to antibody titer analysis and evaluating a few humoral and cellular response markers, showing a more rapid and intense humoral response than individuals without prior infection. However, the basis of these differences has not been explored in depth. In the present work, we analyzed a group of pro and anti-inflammatory cytokines, antibody titers, and cell populations in peripheral blood of individuals with previous SARS-CoV-2 infection using BNT162b2 biologic. Our results suggest that higher antibody concentration in individuals with an earlier disease could be generated by higher production of plasma cells to the detriment of the presence of memory B cells in the bloodstream, which could be related to the high baseline expression of cytokines (IL-6 and IL-10) before vaccination.https://www.frontiersin.org/articles/10.3389/fimmu.2022.946770/fullSARS-CoV-2BNT162b2Interleukin 6Interleukin 10CCR7 B cells |
| spellingShingle | Alberto Ponciano-Gómez Martha Iris Valle-Solis Myriam Campos-Aguilar Rafael Jijón-Lorenzo Elena de la C. Herrera-Cogco Roberto Ramos-Alor César Isaac Bazán-Mendez Gustavo Antonio Pérez-Gil Cervantes Ricardo Ávila-García Abdiel González Aguilar Moises Geovani Salmerón Texale Wilfrido David Tapia-Sánchez Carlos Leonardo Duarte-Martínez Sandra Olivas-Quintero Santiago Cristobal Sigrist-Flores Itzell Alejandrina Gallardo-Ortíz Rafael Villalobos-Molina Adolfo Rene Méndez-Cruz Rafael Jimenez-Flores Leopoldo Santos-Argumedo Juan Pedro Luna-Arias Hector Romero-Ramírez Victor Hugo Rosales-García Victor Hugo Rosales-García Bartolo Avendaño-Borromeo High baseline expression of IL-6 and IL-10 decreased CCR7 B cells in individuals with previous SARS-CoV-2 infection during BNT162b2 vaccination Frontiers in Immunology SARS-CoV-2 BNT162b2 Interleukin 6 Interleukin 10 CCR7 B cells |
| title | High baseline expression of IL-6 and IL-10 decreased CCR7 B cells in individuals with previous SARS-CoV-2 infection during BNT162b2 vaccination |
| title_full | High baseline expression of IL-6 and IL-10 decreased CCR7 B cells in individuals with previous SARS-CoV-2 infection during BNT162b2 vaccination |
| title_fullStr | High baseline expression of IL-6 and IL-10 decreased CCR7 B cells in individuals with previous SARS-CoV-2 infection during BNT162b2 vaccination |
| title_full_unstemmed | High baseline expression of IL-6 and IL-10 decreased CCR7 B cells in individuals with previous SARS-CoV-2 infection during BNT162b2 vaccination |
| title_short | High baseline expression of IL-6 and IL-10 decreased CCR7 B cells in individuals with previous SARS-CoV-2 infection during BNT162b2 vaccination |
| title_sort | high baseline expression of il 6 and il 10 decreased ccr7 b cells in individuals with previous sars cov 2 infection during bnt162b2 vaccination |
| topic | SARS-CoV-2 BNT162b2 Interleukin 6 Interleukin 10 CCR7 B cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.946770/full |
| work_keys_str_mv | AT albertoponcianogomez highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT marthairisvallesolis highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT myriamcamposaguilar highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT rafaeljijonlorenzo highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT elenadelacherreracogco highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT robertoramosalor highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT cesarisaacbazanmendez highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT gustavoantonioperezgilcervantes highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT ricardoavilagarcia highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT abdielgonzalezaguilar highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT moisesgeovanisalmerontexale highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT wilfridodavidtapiasanchez highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT carlosleonardoduartemartinez highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT sandraolivasquintero highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT santiagocristobalsigristflores highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT itzellalejandrinagallardoortiz highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT rafaelvillalobosmolina highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT adolforenemendezcruz highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT rafaeljimenezflores highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT leopoldosantosargumedo highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT juanpedrolunaarias highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT hectorromeroramirez highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT victorhugorosalesgarcia highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT victorhugorosalesgarcia highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination AT bartoloavendanoborromeo highbaselineexpressionofil6andil10decreasedccr7bcellsinindividualswithprevioussarscov2infectionduringbnt162b2vaccination |