SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate

SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate

Spinal commissural axon navigation across the midline in the floor plate requires repulsive forces from local Slit repellents. The long-held view is that Slits push growth cones forward and prevent them from turning back once they became sensitized to these cues after midline crossing. We analyzed w...

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Bibliographic Details
Main Authors: Hugo Ducuing, Thibault Gardette, Aurora Pignata, Karine Kindbeiter, Muriel Bozon, Olivier Thoumine, Céline Delloye-Bourgeois, Servane Tauszig-Delamasure, Valerie Castellani
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
axon guidance
commissural axons
midline crossing
Online Access:https://elifesciences.org/articles/63205

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