Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serum
Background: Pharmacological therapy is one of the therapy modalities which carries the hepatic injury as one of its side effects. Nowadays, curcuma tablets has become choice of hepatoprotector. Other substance which has the possibilities of hepatoprotection activities is chlorophyll. The study is ai...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Indonesian |
| Published: |
Diponegoro University
2016-12-01
|
| Series: | Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition |
| Subjects: | |
| Online Access: | https://ejournal.undip.ac.id/index.php/jgi/article/view/12329 |
| _version_ | 1811240729441206272 |
|---|---|
| author | Kusmadewi Eka Damayanti Noor Wijayahadi Niken Puruhita |
| author_facet | Kusmadewi Eka Damayanti Noor Wijayahadi Niken Puruhita |
| author_sort | Kusmadewi Eka Damayanti |
| collection | DOAJ |
| description | Background: Pharmacological therapy is one of the therapy modalities which carries the hepatic injury as one of its side effects. Nowadays, curcuma tablets has become choice of hepatoprotector. Other substance which has the possibilities of hepatoprotection activities is chlorophyll. The study is aimed to investigate the effect of papaya leaves chlorophyll extracts towards the serum AST and serum ALT levels on high-dose-paracetamol-induced Wistar rats.
Materials and methods: This was an experimental study applying pretest-posttest controlled group design. Twenty eight Wistar rats 8-12 weeks age and weighted 185-220 grams assigned into four groups, namely group I (control), group II (paracetamol 750 mg/kg bw + no hepatoprotector agent), group III (paracetamol 750 mg/kg bw + curcuma 100 mg/kg bw), and group IV (paracetamol 750 mg/kg bw + papaya leaves chlorophyll extracts 300 mg/kg bw). The hepatoprotector agents were administered for a week, while the high dose paracetamol was administered for three consecutive days (day 5, 6, and 7). The pretest samples were drawn on the fifth day before the administration of high dose paracetamol, and the posttest samples were drawn on eightth day.
Results: There were no difference among four groups on serum AST and serum ALT levels before the administration of high dose paracetamol, p=0.522 dan p=0.682, respectively. After the administration of high dose paracetamol, there were differences among four groups on both variables, both p=0.000. The post-hoc test showed that differences happened on all four groups (p<0.05).
Conclusion: Chlorophyll extract of papaya leaves can inhibit liver injury on high-dose-paracetamol-induced-Wistar rats. |
| first_indexed | 2024-04-12T13:25:24Z |
| format | Article |
| id | doaj.art-9deb88a6a1fb46eda9d247e5774822fd |
| institution | Directory Open Access Journal |
| issn | 1858-4942 2338-3119 |
| language | Indonesian |
| last_indexed | 2024-04-12T13:25:24Z |
| publishDate | 2016-12-01 |
| publisher | Diponegoro University |
| record_format | Article |
| series | Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition |
| spelling | doaj.art-9deb88a6a1fb46eda9d247e5774822fd2022-12-22T03:31:22ZindDiponegoro UniversityJurnal Gizi Indonesia: The Indonesian Journal of Nutrition1858-49422338-31192016-12-0141636610.14710/jgi.4.1.63-669709Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serumKusmadewi Eka Damayanti0Noor Wijayahadi1Niken Puruhita2Jurusan Gizi, Fakultas Kedokteran, Universitas Sebelas Maret (UNS)Fakultas Kedokteran, Universitas DiponegoroFakultas Kedokteran, Universitas DiponegoroBackground: Pharmacological therapy is one of the therapy modalities which carries the hepatic injury as one of its side effects. Nowadays, curcuma tablets has become choice of hepatoprotector. Other substance which has the possibilities of hepatoprotection activities is chlorophyll. The study is aimed to investigate the effect of papaya leaves chlorophyll extracts towards the serum AST and serum ALT levels on high-dose-paracetamol-induced Wistar rats. Materials and methods: This was an experimental study applying pretest-posttest controlled group design. Twenty eight Wistar rats 8-12 weeks age and weighted 185-220 grams assigned into four groups, namely group I (control), group II (paracetamol 750 mg/kg bw + no hepatoprotector agent), group III (paracetamol 750 mg/kg bw + curcuma 100 mg/kg bw), and group IV (paracetamol 750 mg/kg bw + papaya leaves chlorophyll extracts 300 mg/kg bw). The hepatoprotector agents were administered for a week, while the high dose paracetamol was administered for three consecutive days (day 5, 6, and 7). The pretest samples were drawn on the fifth day before the administration of high dose paracetamol, and the posttest samples were drawn on eightth day. Results: There were no difference among four groups on serum AST and serum ALT levels before the administration of high dose paracetamol, p=0.522 dan p=0.682, respectively. After the administration of high dose paracetamol, there were differences among four groups on both variables, both p=0.000. The post-hoc test showed that differences happened on all four groups (p<0.05). Conclusion: Chlorophyll extract of papaya leaves can inhibit liver injury on high-dose-paracetamol-induced-Wistar rats.https://ejournal.undip.ac.id/index.php/jgi/article/view/12329Hepatoproteksiklorofildaun pepayaAST serumALT serum |
| spellingShingle | Kusmadewi Eka Damayanti Noor Wijayahadi Niken Puruhita Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serum Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition Hepatoproteksi klorofil daun pepaya AST serum ALT serum |
| title | Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serum |
| title_full | Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serum |
| title_fullStr | Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serum |
| title_full_unstemmed | Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serum |
| title_short | Efek pemberian ekstrak klorofil daun pepaya (carica papaya, linn.) terhadap kadar ast dan alt serum |
| title_sort | efek pemberian ekstrak klorofil daun pepaya carica papaya linn terhadap kadar ast dan alt serum |
| topic | Hepatoproteksi klorofil daun pepaya AST serum ALT serum |
| url | https://ejournal.undip.ac.id/index.php/jgi/article/view/12329 |
| work_keys_str_mv | AT kusmadewiekadamayanti efekpemberianekstrakklorofildaunpepayacaricapapayalinnterhadapkadarastdanaltserum AT noorwijayahadi efekpemberianekstrakklorofildaunpepayacaricapapayalinnterhadapkadarastdanaltserum AT nikenpuruhita efekpemberianekstrakklorofildaunpepayacaricapapayalinnterhadapkadarastdanaltserum |