Breast Sarcomas—How Different Are They from Breast Carcinomas? Clinical, Pathological, Imaging and Treatment Insights
Breast sarcoma (BS) is a very rare and poorly studied condition. This has led to a lack of studies with a high level of evidence and to low efficacy of current clinical management protocols. Here we present our experience in treating this disease in the form of a retrospective case series study incl...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/8/1370 |
| _version_ | 1797605802896261120 |
|---|---|
| author | Iulian Radu Viorel Scripcariu Andrian Panuța Alexandra Rusu Vlad-Adrian Afrăsânie Elena Cojocaru Maria Gabriela Aniței Teodora Alexa-Stratulat Cristina Terinte Cristinel Florin Șerban Bogdan Gafton |
| author_facet | Iulian Radu Viorel Scripcariu Andrian Panuța Alexandra Rusu Vlad-Adrian Afrăsânie Elena Cojocaru Maria Gabriela Aniței Teodora Alexa-Stratulat Cristina Terinte Cristinel Florin Șerban Bogdan Gafton |
| author_sort | Iulian Radu |
| collection | DOAJ |
| description | Breast sarcoma (BS) is a very rare and poorly studied condition. This has led to a lack of studies with a high level of evidence and to low efficacy of current clinical management protocols. Here we present our experience in treating this disease in the form of a retrospective case series study including discussion of clinical, imaging, and pathological features and treatment. We also compare the main clinical and biological features of six cases of BS (phyllodes tumors were excluded) with a cohort of 184 patients with unilateral breast carcinoma (BC) from a previous study performed at our institution. Patients with BS were diagnosed at a younger age, presented no evidence of lymph node invasion or distant metastases, had no multiple or bilateral lesions, and underwent a shorter length of hospital stay versus the breast carcinoma group. Where recommended, adjuvant chemotherapy consisted of an anthracycline-containing regimen, and adjuvant external radiotherapy was delivered in doses of 50 Gy. The comparison data obtained from our BS cases and the ones with BC revealed differences in diagnosis and treatment. A correct pathological diagnosis of breast sarcoma is essential for the right therapeutic approach. We still have more to learn about this entity, but our case series could add value to existing knowledge in a meta-analysis study. |
| first_indexed | 2024-03-11T05:06:16Z |
| format | Article |
| id | doaj.art-9debe32ecc4346f1a013de4bc44c1c6e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T05:06:16Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-9debe32ecc4346f1a013de4bc44c1c6e2023-11-17T18:54:09ZengMDPI AGDiagnostics2075-44182023-04-01138137010.3390/diagnostics13081370Breast Sarcomas—How Different Are They from Breast Carcinomas? Clinical, Pathological, Imaging and Treatment InsightsIulian Radu0Viorel Scripcariu1Andrian Panuța2Alexandra Rusu3Vlad-Adrian Afrăsânie4Elena Cojocaru5Maria Gabriela Aniței6Teodora Alexa-Stratulat7Cristina Terinte8Cristinel Florin Șerban9Bogdan Gafton10First Surgical Oncology Unit, Department of Surgery, Regional Institute of Oncology, 700483 Iasi, RomaniaFirst Surgical Oncology Unit, Department of Surgery, Regional Institute of Oncology, 700483 Iasi, RomaniaDepartment of Surgery, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Medical Oncology, Regional Institute of Oncology, 700483 Iasi, RomaniaDepartment of Medical Oncology, Regional Institute of Oncology, 700483 Iasi, RomaniaDepartment of Morphofunctional Sciences I—Pathology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFirst Surgical Oncology Unit, Department of Surgery, Regional Institute of Oncology, 700483 Iasi, RomaniaDepartment of Medical Oncology, Regional Institute of Oncology, 700483 Iasi, RomaniaDepartment of Pathology, Regional Institute of Oncology, 700483 Iasi, RomaniaDepartment of Pathology, “Dr. C. I. Parhon” Clinical Hospital, 700503 Iasi, RomaniaDepartment of Medical Oncology, Regional Institute of Oncology, 700483 Iasi, RomaniaBreast sarcoma (BS) is a very rare and poorly studied condition. This has led to a lack of studies with a high level of evidence and to low efficacy of current clinical management protocols. Here we present our experience in treating this disease in the form of a retrospective case series study including discussion of clinical, imaging, and pathological features and treatment. We also compare the main clinical and biological features of six cases of BS (phyllodes tumors were excluded) with a cohort of 184 patients with unilateral breast carcinoma (BC) from a previous study performed at our institution. Patients with BS were diagnosed at a younger age, presented no evidence of lymph node invasion or distant metastases, had no multiple or bilateral lesions, and underwent a shorter length of hospital stay versus the breast carcinoma group. Where recommended, adjuvant chemotherapy consisted of an anthracycline-containing regimen, and adjuvant external radiotherapy was delivered in doses of 50 Gy. The comparison data obtained from our BS cases and the ones with BC revealed differences in diagnosis and treatment. A correct pathological diagnosis of breast sarcoma is essential for the right therapeutic approach. We still have more to learn about this entity, but our case series could add value to existing knowledge in a meta-analysis study.https://www.mdpi.com/2075-4418/13/8/1370breast sarcomabreast carcinomadiagnosistreatment |
| spellingShingle | Iulian Radu Viorel Scripcariu Andrian Panuța Alexandra Rusu Vlad-Adrian Afrăsânie Elena Cojocaru Maria Gabriela Aniței Teodora Alexa-Stratulat Cristina Terinte Cristinel Florin Șerban Bogdan Gafton Breast Sarcomas—How Different Are They from Breast Carcinomas? Clinical, Pathological, Imaging and Treatment Insights Diagnostics breast sarcoma breast carcinoma diagnosis treatment |
| title | Breast Sarcomas—How Different Are They from Breast Carcinomas? Clinical, Pathological, Imaging and Treatment Insights |
| title_full | Breast Sarcomas—How Different Are They from Breast Carcinomas? Clinical, Pathological, Imaging and Treatment Insights |
| title_fullStr | Breast Sarcomas—How Different Are They from Breast Carcinomas? Clinical, Pathological, Imaging and Treatment Insights |
| title_full_unstemmed | Breast Sarcomas—How Different Are They from Breast Carcinomas? Clinical, Pathological, Imaging and Treatment Insights |
| title_short | Breast Sarcomas—How Different Are They from Breast Carcinomas? Clinical, Pathological, Imaging and Treatment Insights |
| title_sort | breast sarcomas how different are they from breast carcinomas clinical pathological imaging and treatment insights |
| topic | breast sarcoma breast carcinoma diagnosis treatment |
| url | https://www.mdpi.com/2075-4418/13/8/1370 |
| work_keys_str_mv | AT iulianradu breastsarcomashowdifferentaretheyfrombreastcarcinomasclinicalpathologicalimagingandtreatmentinsights AT viorelscripcariu breastsarcomashowdifferentaretheyfrombreastcarcinomasclinicalpathologicalimagingandtreatmentinsights AT andrianpanuta breastsarcomashowdifferentaretheyfrombreastcarcinomasclinicalpathologicalimagingandtreatmentinsights AT alexandrarusu breastsarcomashowdifferentaretheyfrombreastcarcinomasclinicalpathologicalimagingandtreatmentinsights AT vladadrianafrasanie breastsarcomashowdifferentaretheyfrombreastcarcinomasclinicalpathologicalimagingandtreatmentinsights AT elenacojocaru breastsarcomashowdifferentaretheyfrombreastcarcinomasclinicalpathologicalimagingandtreatmentinsights AT mariagabrielaanitei breastsarcomashowdifferentaretheyfrombreastcarcinomasclinicalpathologicalimagingandtreatmentinsights AT teodoraalexastratulat breastsarcomashowdifferentaretheyfrombreastcarcinomasclinicalpathologicalimagingandtreatmentinsights AT cristinaterinte breastsarcomashowdifferentaretheyfrombreastcarcinomasclinicalpathologicalimagingandtreatmentinsights AT cristinelflorinserban breastsarcomashowdifferentaretheyfrombreastcarcinomasclinicalpathologicalimagingandtreatmentinsights AT bogdangafton breastsarcomashowdifferentaretheyfrombreastcarcinomasclinicalpathologicalimagingandtreatmentinsights |