Pharmaceutical Characterization and In Vivo Evaluation of Orlistat Formulations Prepared by the Supercritical Melt-Adsorption Method Using Carbon Dioxide: Effects of Mesoporous Silica Type

Pharmaceutical Characterization and In Vivo Evaluation of Orlistat Formulations Prepared by the Supercritical Melt-Adsorption Method Using Carbon Dioxide: Effects of Mesoporous Silica Type

Orlistat, an anti-obesity drug, has two critical issues—the first is its low efficacy due to low water solubility and the second is side effects such as oily spotting due to its lipase inhibition. The present study was designed to propose a solution using a formulation with mesoporous silica to simu...

書誌詳細
主要な著者:	Heejun Park, Kwang-Ho Cha, Seung Hyeon Hong, Sharif Md Abuzar, Seungyeol Lee, Eun-Sol Ha, Jeong-Soo Kim, In-Hwan Baek, Min-Soo Kim, Sung-Joo Hwang
フォーマット:	論文
言語:	English
出版事項:	MDPI AG 2020-04-01
シリーズ:	Pharmaceutics
主題:	orlistat mesoporous silica supercritical melt-adsorption crystallinity in vivo evaluation
オンライン･アクセス:	https://www.mdpi.com/1999-4923/12/4/333

類似資料

Melt Amorphisation of Orlistat with Mesoporous Silica Using a Supercritical Carbon Dioxide: Effects of Pressure, Temperature, and Drug Loading Ratio and Comparison with Other Conventional Amorphisation Methods
著者:: Heejun Park, 等
出版事項: (2020-04-01)

Orlistat induces weight loss and improves fertility in patients with PCOS
著者:: Svetlana Yur'evna Vorotnikova
出版事項: (2015-04-01)

Efficacy of Orlistat on Hyperbilirubinemia in Full Term Neonates
著者:: M Habibi, 等
出版事項: (2024-03-01)

Evaluation of effectiveness of orlistat in complexed obesity treatment in teenagers with metabolic syndrome
出版事項: (2011-12-01)

The effect of orlistat on postprandial hypertriglyceridemia by oral fat loading test: a systematic review
著者:: Ana Rodríguez-Valle, 等

orlistat improves release of gut hormones increasing satiety in obese women
著者:: Teona Albertovna Shvangiradze
出版事項: (2014-12-01)

The influence of orlistat (Xenical) therapy on the parameters of lipid metabolism in patients with obesity
出版事項: (2009-06-01)

Opyt primeneniya preparata Orsoten (orlistat)u bol'nykh ozhireniem
出版事項: (2010-03-01)

LONG-TERM EFFECTS OF ORLISTAT ON EATING BEHAVIOR OF OBESITY PATIENTS
著者:: E. V. Korneeva
出版事項: (2015-09-01)

The effect of orlistat and weight loss diet on plasma ghrelin and obestatin
著者:: Baris Pamuk, 等
出版事項: (2018-01-01)

Kardiovaskulyarnoe «bremya» ozhireniyai profilakticheskie vozmozhnostiKsenikala (orlistat 120 mg)
出版事項: (2010-06-01)

A comparative study of the efficacy and safety of the original and generic orlistat in obese patients in the PROFIL register
著者:: A. V. Zakharova, 等
出版事項: (2016-03-01)

ORLISTAT IN COMBINATION THERAPY OF OBESITY AND TYPE 2 DIABETES
著者:: A. M. Mkrtumyan, 等
出版事項: (2017-12-01)

The effect of orlistat on body weight in obese Czech adults
著者:: Pavlík Vladimír, 等
出版事項: (2013-10-01)

An Unexpected Result of Obesity Treatment: Orlistat-Related Acute Pancreatitis
著者:: Murat Kose, 等
出版事項: (2015-05-01)

Histopathological Study of Orlistat and Rosemary Aqueous Extract in the Brain and Liver of Obese Male Rats
著者:: Alyaa, A. Al-Safo, 等
出版事項: (2022-04-01)

Development and validation by statistical treatment of stability indicating RP-HPLC method for quantification of Orlistat in Orlistat-loaded solid dispersion
著者:: Kiran Singh Sharma, 等
出版事項: (2021-02-01)

Preparation of Hot-Melt-Extruded Solid Dispersion Based on Pre-Formulation Strategies and Its Enhanced Therapeutic Efficacy
著者:: Seon-Kwang Lee, 等
出版事項: (2023-11-01)

Effect of orlistat and aquatic extract of Rosmarinus officinalis leaves in histopathological changes in kidney of albino rat
著者:: Alya A. Al-Safo, 等
出版事項: (2022-04-01)

Effect of two days treatment with orlistat on plasma leptin in obese patients without weight loss
著者:: Ana Rodríguez-Valle, 等

Several notes on the melting behavior of mesoporous materials
著者:: A.V. Shishulin, 等
出版事項: (2024-12-01)

Comparison of Metformin and Orlistat in Anovulatory, Overweight and Obese Women with Polycystic Ovarian Syndrome
著者:: Uzma Gul, 等
出版事項: (2023-06-01)

Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation
著者:: Heejun Park, 等
出版事項: (2021-11-01)

Pharmacovigilance analysis of orlistat adverse events based on the FDA adverse event reporting system (FAERS) database
著者:: Jinfeng Zhu, 等
出版事項: (2024-07-01)

Anti-Atherogenic Effects of Orlistat on Obesity-Induced Vascular Oxidative Stress Rat Model
著者:: Zaidatul Akmal Othman, 等
出版事項: (2021-02-01)

Orlistat in polycystic ovarian syndrome reduces weight with improvement in lipid profile and pregnancy rates
著者:: Pratap Kumar, 等
出版事項: (2014-01-01)

Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysis
著者:: Zeinab Nikniaz, 等
出版事項: (2023-07-01)

Clinical case: Effectiveness of combined therapyOrlistat and Irbesartan at the Metabolic syndrome patient with Arterial hypertension
著者:: K P Ivanov, 等
出版事項: (2009-03-01)

The Application of Quantitative 1H-NMR for the Determination of Orlistat in Tablets
著者:: Shanshan Sun, 等
出版事項: (2017-09-01)

Metabolic abnormalities and behavioral peculiarities in patients with obesity: statics and dynamics on Orlistat therapy
出版事項: (2009-09-01)

Dynamics of lipid profile and circadian pressure rhythms in patients with obesity and arterial hypertension, treated with orlistat and its combination with ACE inhibitors
著者:: A. G. Avtandilov, 等
出版事項: (2005-02-01)

Demographic and clinical characteristics, and adverse reactions of people with overweight and obesity consumers of orlistat, attended by a call center (2009 – 2017)
著者:: Sandra Rizo Treviño
出版事項: (2018-10-01)

Interferencia en la absorción de levotiroxina asociada al uso de orlistat
著者:: Carlos Esteban Builes Montaño, 等
出版事項: (2017-03-01)

The Use of Orlistat in an Adult with Lipoprotein Lipase Deficiency: A Case Report
著者:: Zachary S. Jarrett, DO, 等
出版事項: (2022-03-01)

Detection of biological active substances and lipase inhibitors from aqueous extracts of some legumes in comparison with Orlistat drug
著者:: K. A. A. Al- Khafaji, 等
出版事項: (2014-12-01)

Orlistat and ezetimibe could differently alleviate the high-fat diet-induced obesity phenotype by modulating the gut microbiota
著者:: Jin Jin, 等
出版事項: (2022-08-01)

Orlistat-loaded solid SNEDDS for the enhanced solubility, dissolution, and in vivo performance
著者:: Kim DH, 等
出版事項: (2018-11-01)

Effects of a novel weight-loss combination product containing orlistat and resveratrol on obesity: A multicenter randomized controlled study (EC-FIT)
著者:: Khin Maung Win, 等
出版事項: (2025-03-01)

Orlistat for the treatment of antipsychotic-induced weight gain: an eight-week multicenter, randomized, placebo-controlled, double-blind trial
著者:: Peng Xie, 等
出版事項: (2024-07-01)

Systematic review of the clinical efficacy of sibutramine and orlistat in weigth loss, quality of life and its adverse effects in obese adolescents Revisión sistemática sobre la eficacia clínica de la sibutramina y el orlistat en la pérdida de peso, calidad de vida y sus efectos adversos en obesos adolescentes
著者:: E. García Díaz, 等
出版事項: (2011-06-01)