Passive performance evaluation and validation of a viscous impeller pump for subpulmonary fontan circulatory support
Abstract Patients with single ventricle defects undergoing the Fontan procedure eventually face Fontan failure. Long-term cavopulmonary assist devices using rotary pump technologies are currently being developed as a subpulmonary power source to prevent and treat Fontan failure. Low hydraulic resist...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38559-y |
| _version_ | 1797559558581780480 |
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| author | Weiguang Yang Timothy A. Conover Richard S. Figliola Guruprasad A. Giridharan Alison L. Marsden Mark D. Rodefeld |
| author_facet | Weiguang Yang Timothy A. Conover Richard S. Figliola Guruprasad A. Giridharan Alison L. Marsden Mark D. Rodefeld |
| author_sort | Weiguang Yang |
| collection | DOAJ |
| description | Abstract Patients with single ventricle defects undergoing the Fontan procedure eventually face Fontan failure. Long-term cavopulmonary assist devices using rotary pump technologies are currently being developed as a subpulmonary power source to prevent and treat Fontan failure. Low hydraulic resistance is a critical safety requirement in the event of pump failure (0 RPM) as a modest 2 mmHg cavopulmonary pressure drop can compromise patient hemodynamics. The goal of this study is therefore to assess the passive performance of a viscous impeller pump (VIP) we are developing for Fontan patients, and validate flow simulations against in-vitro data. Two different blade heights (1.09 mm vs 1.62 mm) and a blank housing model were tested using a mock circulatory loop (MCL) with cardiac output ranging from 3 to 11 L/min. Three-dimensional flow simulations were performed and compared against MCL data. In-silico and MCL results demonstrated a pressure drop of < 2 mmHg at a cardiac output of 7 L/min for both blade heights. There was good agreement between simulation and MCL results for pressure loss (mean difference − 0.23 mmHg 95% CI [0.24–0.71]). Compared to the blank housing model, low wall shear stress area and oscillatory shear index on the pump surface were low, and mean washout times were within 2 s. This study demonstrated the low resistance characteristic of current VIP designs in the failed condition that results in clinically acceptable minimal pressure loss without increased washout time as compared to a blank housing model under normal cardiac output in Fontan patients. |
| first_indexed | 2024-03-10T17:47:05Z |
| format | Article |
| id | doaj.art-9def049127d24e138742b9dee168441f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:47:05Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9def049127d24e138742b9dee168441f2023-11-20T09:28:52ZengNature PortfolioScientific Reports2045-23222023-08-0113111310.1038/s41598-023-38559-yPassive performance evaluation and validation of a viscous impeller pump for subpulmonary fontan circulatory supportWeiguang Yang0Timothy A. Conover1Richard S. Figliola2Guruprasad A. Giridharan3Alison L. Marsden4Mark D. Rodefeld5Department of Pediatrics (Cardiology), Stanford UniversityDepartments of Mechanical Engineering, Clemson UniversityDepartments of Mechanical Engineering, Clemson UniversityDepartment of Bioengineering, University of LouisvilleDepartment of Pediatrics (Cardiology), Stanford UniversitySection of Cardiothoracic Surgery, Department of Surgery, Indiana University School of MedicineAbstract Patients with single ventricle defects undergoing the Fontan procedure eventually face Fontan failure. Long-term cavopulmonary assist devices using rotary pump technologies are currently being developed as a subpulmonary power source to prevent and treat Fontan failure. Low hydraulic resistance is a critical safety requirement in the event of pump failure (0 RPM) as a modest 2 mmHg cavopulmonary pressure drop can compromise patient hemodynamics. The goal of this study is therefore to assess the passive performance of a viscous impeller pump (VIP) we are developing for Fontan patients, and validate flow simulations against in-vitro data. Two different blade heights (1.09 mm vs 1.62 mm) and a blank housing model were tested using a mock circulatory loop (MCL) with cardiac output ranging from 3 to 11 L/min. Three-dimensional flow simulations were performed and compared against MCL data. In-silico and MCL results demonstrated a pressure drop of < 2 mmHg at a cardiac output of 7 L/min for both blade heights. There was good agreement between simulation and MCL results for pressure loss (mean difference − 0.23 mmHg 95% CI [0.24–0.71]). Compared to the blank housing model, low wall shear stress area and oscillatory shear index on the pump surface were low, and mean washout times were within 2 s. This study demonstrated the low resistance characteristic of current VIP designs in the failed condition that results in clinically acceptable minimal pressure loss without increased washout time as compared to a blank housing model under normal cardiac output in Fontan patients.https://doi.org/10.1038/s41598-023-38559-y |
| spellingShingle | Weiguang Yang Timothy A. Conover Richard S. Figliola Guruprasad A. Giridharan Alison L. Marsden Mark D. Rodefeld Passive performance evaluation and validation of a viscous impeller pump for subpulmonary fontan circulatory support Scientific Reports |
| title | Passive performance evaluation and validation of a viscous impeller pump for subpulmonary fontan circulatory support |
| title_full | Passive performance evaluation and validation of a viscous impeller pump for subpulmonary fontan circulatory support |
| title_fullStr | Passive performance evaluation and validation of a viscous impeller pump for subpulmonary fontan circulatory support |
| title_full_unstemmed | Passive performance evaluation and validation of a viscous impeller pump for subpulmonary fontan circulatory support |
| title_short | Passive performance evaluation and validation of a viscous impeller pump for subpulmonary fontan circulatory support |
| title_sort | passive performance evaluation and validation of a viscous impeller pump for subpulmonary fontan circulatory support |
| url | https://doi.org/10.1038/s41598-023-38559-y |
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