Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits
There is a renewed interest on the reliance of food-based bioactive compounds as sources of nutritive factors and health-beneficial chemical compounds. Among these food components, several proteins from foods have been shown to promote health and wellness as seen in proteins such as α/γ-conglutins f...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/13/9/3266 |
| _version_ | 1797517743597027328 |
|---|---|
| author | Innocent U. Okagu Joseph C. Ndefo Emmanuel C. Aham Joy I. Obeme-Nmom Precious E. Agboinghale Rita N. Aguchem Regina N. Nechi Carmen Lammi |
| author_facet | Innocent U. Okagu Joseph C. Ndefo Emmanuel C. Aham Joy I. Obeme-Nmom Precious E. Agboinghale Rita N. Aguchem Regina N. Nechi Carmen Lammi |
| author_sort | Innocent U. Okagu |
| collection | DOAJ |
| description | There is a renewed interest on the reliance of food-based bioactive compounds as sources of nutritive factors and health-beneficial chemical compounds. Among these food components, several proteins from foods have been shown to promote health and wellness as seen in proteins such as α/γ-conglutins from the seeds of <i>Lupinus</i> species (Lupin)<i>,</i> a genus of leguminous plant that are widely used in traditional medicine for treating chronic diseases. Lupin-derived peptides (LDPs) are increasingly being explored and they have been shown to possess multifunctional health improving properties. This paper discusses the intestinal transport, bioavailability and biological activities of LDPs, focusing on molecular mechanisms of action as reported in in vitro, cell culture, animal and human studies. The potentials of several LDPs to demonstrate multitarget mechanism of regulation of glucose and lipid metabolism, chemo- and osteoprotective properties, and antioxidant and anti-inflammatory activities position LDPs as good candidates for nutraceutical development for the prevention and management of medical conditions whose etiology are multifactorial. |
| first_indexed | 2024-03-10T07:20:28Z |
| format | Article |
| id | doaj.art-9df17e787b71459d914eea2843bcf729 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T07:20:28Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9df17e787b71459d914eea2843bcf7292023-11-22T14:40:00ZengMDPI AGNutrients2072-66432021-09-01139326610.3390/nu13093266Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health BenefitsInnocent U. Okagu0Joseph C. Ndefo1Emmanuel C. Aham2Joy I. Obeme-Nmom3Precious E. Agboinghale4Rita N. Aguchem5Regina N. Nechi6Carmen Lammi7Department of Biochemistry, University of Nigeria, Nsukka 410001, NigeriaDepartment of Science Laboratory Technology, University of Nigeria, Nsukka 410001, NigeriaDepartment of Biochemistry, University of Nigeria, Nsukka 410001, NigeriaDepartment of Biochemistry, College of Pure and Applied Sciences, Landmark University, PMB 1001, Omu-Aran 251101, NigeriaDepartment of Biochemistry, Afe Babalola University, Ado-Ekiti 360001, NigeriaDepartment of Biochemistry, University of Nigeria, Nsukka 410001, NigeriaFaculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, NigeriaDepartment of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milano, ItalyThere is a renewed interest on the reliance of food-based bioactive compounds as sources of nutritive factors and health-beneficial chemical compounds. Among these food components, several proteins from foods have been shown to promote health and wellness as seen in proteins such as α/γ-conglutins from the seeds of <i>Lupinus</i> species (Lupin)<i>,</i> a genus of leguminous plant that are widely used in traditional medicine for treating chronic diseases. Lupin-derived peptides (LDPs) are increasingly being explored and they have been shown to possess multifunctional health improving properties. This paper discusses the intestinal transport, bioavailability and biological activities of LDPs, focusing on molecular mechanisms of action as reported in in vitro, cell culture, animal and human studies. The potentials of several LDPs to demonstrate multitarget mechanism of regulation of glucose and lipid metabolism, chemo- and osteoprotective properties, and antioxidant and anti-inflammatory activities position LDPs as good candidates for nutraceutical development for the prevention and management of medical conditions whose etiology are multifactorial.https://www.mdpi.com/2072-6643/13/9/3266lupin<i>Lupinus species</i>lupin protein hydrolysateslupin-derived peptidesfunctional foodsbioactive peptides |
| spellingShingle | Innocent U. Okagu Joseph C. Ndefo Emmanuel C. Aham Joy I. Obeme-Nmom Precious E. Agboinghale Rita N. Aguchem Regina N. Nechi Carmen Lammi Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits Nutrients lupin <i>Lupinus species</i> lupin protein hydrolysates lupin-derived peptides functional foods bioactive peptides |
| title | Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits |
| title_full | Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits |
| title_fullStr | Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits |
| title_full_unstemmed | Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits |
| title_short | Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits |
| title_sort | lupin derived bioactive peptides intestinal transport bioavailability and health benefits |
| topic | lupin <i>Lupinus species</i> lupin protein hydrolysates lupin-derived peptides functional foods bioactive peptides |
| url | https://www.mdpi.com/2072-6643/13/9/3266 |
| work_keys_str_mv | AT innocentuokagu lupinderivedbioactivepeptidesintestinaltransportbioavailabilityandhealthbenefits AT josephcndefo lupinderivedbioactivepeptidesintestinaltransportbioavailabilityandhealthbenefits AT emmanuelcaham lupinderivedbioactivepeptidesintestinaltransportbioavailabilityandhealthbenefits AT joyiobemenmom lupinderivedbioactivepeptidesintestinaltransportbioavailabilityandhealthbenefits AT preciouseagboinghale lupinderivedbioactivepeptidesintestinaltransportbioavailabilityandhealthbenefits AT ritanaguchem lupinderivedbioactivepeptidesintestinaltransportbioavailabilityandhealthbenefits AT reginannechi lupinderivedbioactivepeptidesintestinaltransportbioavailabilityandhealthbenefits AT carmenlammi lupinderivedbioactivepeptidesintestinaltransportbioavailabilityandhealthbenefits |