Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that mediates a wide array of biologic effects through its interaction with a family of five G protein-coupled receptors. Cytokines and growth factors interact with this signaling pathway in a variety of ways, including both activation and re...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2008-07-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520347106 |
| _version_ | 1831592256794001408 |
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| author | Deborah A. Lebman Sarah Spiegel |
| author_facet | Deborah A. Lebman Sarah Spiegel |
| author_sort | Deborah A. Lebman |
| collection | DOAJ |
| description | Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that mediates a wide array of biologic effects through its interaction with a family of five G protein-coupled receptors. Cytokines and growth factors interact with this signaling pathway in a variety of ways, including both activation and regulation of the expression of the enzymes that regulate synthesis and degradation of S1P. Not only do many growth factors and cytokines stimulate S1P production, leading to transactivation of S1P receptors, ligation of S1P receptors by S1P can also transactivate growth factor tyrosine kinase receptors and stimulate growth factor and cytokine signaling cascades.XXX This review discusses the mechanisms involved in cross-talk between S1P, cytokines, and growth factors and the impact of that cross-talk on cell signaling and cell biology. |
| first_indexed | 2024-12-18T01:40:17Z |
| format | Article |
| id | doaj.art-9df2a6e979f6456fa3687c3fe48cdab7 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-18T01:40:17Z |
| publishDate | 2008-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-9df2a6e979f6456fa3687c3fe48cdab72022-12-21T21:25:21ZengElsevierJournal of Lipid Research0022-22752008-07-0149713881394Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1Deborah A. Lebman0Sarah Spiegel1Department of Microbiology and Immunology and Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, VA 23298Department of Molecular Biology, and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that mediates a wide array of biologic effects through its interaction with a family of five G protein-coupled receptors. Cytokines and growth factors interact with this signaling pathway in a variety of ways, including both activation and regulation of the expression of the enzymes that regulate synthesis and degradation of S1P. Not only do many growth factors and cytokines stimulate S1P production, leading to transactivation of S1P receptors, ligation of S1P receptors by S1P can also transactivate growth factor tyrosine kinase receptors and stimulate growth factor and cytokine signaling cascades.XXX This review discusses the mechanisms involved in cross-talk between S1P, cytokines, and growth factors and the impact of that cross-talk on cell signaling and cell biology.http://www.sciencedirect.com/science/article/pii/S0022227520347106transforming growth factor betasphingosine kinaseG protein-coupled receptorgrowth factor receptor |
| spellingShingle | Deborah A. Lebman Sarah Spiegel Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1 Journal of Lipid Research transforming growth factor beta sphingosine kinase G protein-coupled receptor growth factor receptor |
| title | Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1 |
| title_full | Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1 |
| title_fullStr | Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1 |
| title_full_unstemmed | Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1 |
| title_short | Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1 |
| title_sort | thematic review series sphingolipids cross talk at the crossroads of sphingosine 1 phosphate growth factors and cytokine signaling 1 |
| topic | transforming growth factor beta sphingosine kinase G protein-coupled receptor growth factor receptor |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520347106 |
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