From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease
Abstract Current research has described improving multisystem disease and organ function through dietary nitrate (DN) supplementation. They have provided some evidence that these floras with nitrate (NO3 −) reductase are mediators of the underlying mechanism. Symbiotic bacteria with nitrate reductas...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01413-y |
| _version_ | 1797453490989039616 |
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| author | Hongyu Liu Yisheng Huang Mingshu Huang Min Wang Yue Ming Weixing Chen Yuanxin Chen Zhengming Tang Bo Jia |
| author_facet | Hongyu Liu Yisheng Huang Mingshu Huang Min Wang Yue Ming Weixing Chen Yuanxin Chen Zhengming Tang Bo Jia |
| author_sort | Hongyu Liu |
| collection | DOAJ |
| description | Abstract Current research has described improving multisystem disease and organ function through dietary nitrate (DN) supplementation. They have provided some evidence that these floras with nitrate (NO3 −) reductase are mediators of the underlying mechanism. Symbiotic bacteria with nitrate reductase activity (NRA) are found in the human digestive tract, including the mouth, esophagus and gastrointestinal tract (GT). Nitrate in food can be converted to nitrite under the tongue or in the stomach by these symbiotic bacteria. Then, nitrite is transformed to nitric oxide (NO) by non-enzymatic synthesis. NO is currently recognized as a potent bioactive agent with biological activities, such as vasodilation, regulation of cardiomyocyte function, neurotransmission, suppression of platelet agglutination, and prevention of vascular smooth muscle cell proliferation. NO also can be produced through the conventional l-arginine–NO synthase (l-NOS) pathway, whereas endogenous NO production by l-arginine is inhibited under hypoxia–ischemia or disease conditions. In contrast, exogenous NO3 −/NO2 −/NO activity is enhanced and becomes a practical supplemental pathway for NO in the body, playing an essential role in various physiological activities. Moreover, many diseases (such as metabolic or geriatric diseases) are primarily associated with disorders of endogenous NO synthesis, and NO generation from the exogenous NO3 −/NO2 −/NO route can partially alleviate the disease progression. The imbalance of NO in the body may be one of the potential mechanisms of disease development. Therefore, the impact of these floras with nitrate reductase on host systemic health through exogenous NO3 −/NO2 −/NO pathway production of NO or direct regulation of floras ecological balance is essential (e.g., regulation of body homeostasis, amelioration of diseases, etc.). This review summarizes the bacteria with nitrate reductase in humans, emphasizing the relationship between the metabolic processes of this microflora and host systemic health and disease. The potential effects of nitrate reduction bacteria on human health and disease were also highlighted in disease models from different human systems, including digestive, cardiovascular, endocrine, nervous, respiratory, and urinary systems, providing innovative ideas for future disease diagnosis and treatment based on nitrate reduction bacteria. |
| first_indexed | 2024-03-09T15:22:35Z |
| format | Article |
| id | doaj.art-9df464d35b0d44e1ab640ae104e4a936 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-09T15:22:35Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-9df464d35b0d44e1ab640ae104e4a9362023-11-26T12:42:22ZengBMCEuropean Journal of Medical Research2047-783X2023-10-0128112410.1186/s40001-023-01413-yFrom nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and diseaseHongyu Liu0Yisheng Huang1Mingshu Huang2Min Wang3Yue Ming4Weixing Chen5Yuanxin Chen6Zhengming Tang7Bo Jia8Department of Oral Surgery, School of Stomatology, Southern Medical UniversityDepartment of Oral Surgery, School of Stomatology, Southern Medical UniversityDepartment of Oral Surgery, School of Stomatology, Southern Medical UniversityDepartment of Oral Surgery, School of Stomatology, Southern Medical UniversityDepartment of Oral Surgery, School of Stomatology, Southern Medical UniversityDepartment of Oral Surgery, School of Stomatology, Southern Medical UniversityDepartment of Oral Surgery, School of Stomatology, Southern Medical UniversityDepartment of Oral Surgery, School of Stomatology, Southern Medical UniversityDepartment of Oral Surgery, School of Stomatology, Southern Medical UniversityAbstract Current research has described improving multisystem disease and organ function through dietary nitrate (DN) supplementation. They have provided some evidence that these floras with nitrate (NO3 −) reductase are mediators of the underlying mechanism. Symbiotic bacteria with nitrate reductase activity (NRA) are found in the human digestive tract, including the mouth, esophagus and gastrointestinal tract (GT). Nitrate in food can be converted to nitrite under the tongue or in the stomach by these symbiotic bacteria. Then, nitrite is transformed to nitric oxide (NO) by non-enzymatic synthesis. NO is currently recognized as a potent bioactive agent with biological activities, such as vasodilation, regulation of cardiomyocyte function, neurotransmission, suppression of platelet agglutination, and prevention of vascular smooth muscle cell proliferation. NO also can be produced through the conventional l-arginine–NO synthase (l-NOS) pathway, whereas endogenous NO production by l-arginine is inhibited under hypoxia–ischemia or disease conditions. In contrast, exogenous NO3 −/NO2 −/NO activity is enhanced and becomes a practical supplemental pathway for NO in the body, playing an essential role in various physiological activities. Moreover, many diseases (such as metabolic or geriatric diseases) are primarily associated with disorders of endogenous NO synthesis, and NO generation from the exogenous NO3 −/NO2 −/NO route can partially alleviate the disease progression. The imbalance of NO in the body may be one of the potential mechanisms of disease development. Therefore, the impact of these floras with nitrate reductase on host systemic health through exogenous NO3 −/NO2 −/NO pathway production of NO or direct regulation of floras ecological balance is essential (e.g., regulation of body homeostasis, amelioration of diseases, etc.). This review summarizes the bacteria with nitrate reductase in humans, emphasizing the relationship between the metabolic processes of this microflora and host systemic health and disease. The potential effects of nitrate reduction bacteria on human health and disease were also highlighted in disease models from different human systems, including digestive, cardiovascular, endocrine, nervous, respiratory, and urinary systems, providing innovative ideas for future disease diagnosis and treatment based on nitrate reduction bacteria.https://doi.org/10.1186/s40001-023-01413-yOral microfloraEsophageal microfloraGastrointestinal microfloraNitrate-reducing bacteriaNitrate reductaseNitrate |
| spellingShingle | Hongyu Liu Yisheng Huang Mingshu Huang Min Wang Yue Ming Weixing Chen Yuanxin Chen Zhengming Tang Bo Jia From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease European Journal of Medical Research Oral microflora Esophageal microflora Gastrointestinal microflora Nitrate-reducing bacteria Nitrate reductase Nitrate |
| title | From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease |
| title_full | From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease |
| title_fullStr | From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease |
| title_full_unstemmed | From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease |
| title_short | From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease |
| title_sort | from nitrate to no potential effects of nitrate reducing bacteria on systemic health and disease |
| topic | Oral microflora Esophageal microflora Gastrointestinal microflora Nitrate-reducing bacteria Nitrate reductase Nitrate |
| url | https://doi.org/10.1186/s40001-023-01413-y |
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