Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD+/NADH ratio

Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD+/NADH ratio

Abstract Background Non-alcoholic fatty liver disease is often associated with obesity, insulin resistance, dyslipidemia, and the metabolic syndrome in addition to mitochondrial dysfunction and nicotinamide adenine dinucleotide (NAD+) deficiency. The aim of this study was to investigate how inhibiti...

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Bibliographic Details
Main Authors: Rolf K. Berge, Daniel Cacabelos, Rosa Señarís, Jan Erik Nordrehaug, Ottar Nygård, Jon Skorve, Bodil Bjørndal
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Lipids in Health and Disease
Subjects:
Non-alcoholic fatty liver
Kynurenine metabolites
Hepatic NAD metabolism
Mouse model
Online Access:http://link.springer.com/article/10.1186/s12944-020-01271-1

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