LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases
Long non-coding RNAs (lncRNAs) exhibit a length more than 200 nucleotides and they are characterized by non-coding RNAs (ncRNA) not encoded into proteins. Over the past few years, the role and development of lncRNAs have aroused the rising attention of researchers. To be specific, KCNQ1OT1, the KCNQ...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-11-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304221000957 |
| _version_ | 1827267679567740928 |
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| author | Fangqi Xia Yaqi Wang Mengzhen Xue Leiqi Zhu Dengke Jia Yue Shi Yan Gao Luoying Li Yuanyang Li Silong Chen Guangfu Xu Ding Yuan Chengfu Yuan |
| author_facet | Fangqi Xia Yaqi Wang Mengzhen Xue Leiqi Zhu Dengke Jia Yue Shi Yan Gao Luoying Li Yuanyang Li Silong Chen Guangfu Xu Ding Yuan Chengfu Yuan |
| author_sort | Fangqi Xia |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) exhibit a length more than 200 nucleotides and they are characterized by non-coding RNAs (ncRNA) not encoded into proteins. Over the past few years, the role and development of lncRNAs have aroused the rising attention of researchers. To be specific, KCNQ1OT1, the KCNQ1 opposite strand/antisense transcript 1, is clearly classified as a regulatory ncRNA. KCNQ1OT1 is capable of interacting with miRNAs, RNAs and proteins, thereby affecting gene expression and various cell functions (e.g., cell proliferation, migration, epithelial–mesenchymal transition (EMT), apoptosis, viability, autophagy and inflammation). KCNQ1OT1 is dysregulated in a wide range of human diseases (e.g., cardiovascular disease, cancer, diabetes, osteoarthritis, osteoporosis and cataract), and it is speculated to act as a therapeutic target for treating various human diseases. On the whole, this review aims to explore the biological functions, underlying mechanisms and pathogenic roles of KCNQ1OT1 in human diseases. |
| first_indexed | 2024-03-12T10:07:35Z |
| format | Article |
| id | doaj.art-9df592cb877f40c28b76193961178261 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T04:37:35Z |
| publishDate | 2022-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-9df592cb877f40c28b761939611782612024-04-28T00:32:58ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422022-11-019615561565LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseasesFangqi Xia0Yaqi Wang1Mengzhen Xue2Leiqi Zhu3Dengke Jia4Yue Shi5Yan Gao6Luoying Li7Yuanyang Li8Silong Chen9Guangfu Xu10Ding Yuan11Chengfu Yuan12College of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR ChinaCollege of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR ChinaCollege of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR ChinaCollege of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR ChinaCollege of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR ChinaCollege of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR ChinaCollege of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR ChinaCollege of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR ChinaCollege of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR ChinaCollege of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR ChinaCollege of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR ChinaCollege of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR China; Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China Three Gorges, Yichang, Hubei 443002, PR China; Corresponding author. College of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR China.College of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR China; Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China Three Gorges, Yichang, Hubei 443002, PR China; Hubei Key Laboratory of Tumour Microenvironment and Immunotherapy, China Three Gorges University, Yichang, Hubei 443002, PR China; Corresponding author. College of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR China.Long non-coding RNAs (lncRNAs) exhibit a length more than 200 nucleotides and they are characterized by non-coding RNAs (ncRNA) not encoded into proteins. Over the past few years, the role and development of lncRNAs have aroused the rising attention of researchers. To be specific, KCNQ1OT1, the KCNQ1 opposite strand/antisense transcript 1, is clearly classified as a regulatory ncRNA. KCNQ1OT1 is capable of interacting with miRNAs, RNAs and proteins, thereby affecting gene expression and various cell functions (e.g., cell proliferation, migration, epithelial–mesenchymal transition (EMT), apoptosis, viability, autophagy and inflammation). KCNQ1OT1 is dysregulated in a wide range of human diseases (e.g., cardiovascular disease, cancer, diabetes, osteoarthritis, osteoporosis and cataract), and it is speculated to act as a therapeutic target for treating various human diseases. On the whole, this review aims to explore the biological functions, underlying mechanisms and pathogenic roles of KCNQ1OT1 in human diseases.http://www.sciencedirect.com/science/article/pii/S2352304221000957Cell functionsHuman diseasesKCNQ1OT1Long non–coding RNARegulatory ncRNA |
| spellingShingle | Fangqi Xia Yaqi Wang Mengzhen Xue Leiqi Zhu Dengke Jia Yue Shi Yan Gao Luoying Li Yuanyang Li Silong Chen Guangfu Xu Ding Yuan Chengfu Yuan LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases Genes and Diseases Cell functions Human diseases KCNQ1OT1 Long non–coding RNA Regulatory ncRNA |
| title | LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases |
| title_full | LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases |
| title_fullStr | LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases |
| title_full_unstemmed | LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases |
| title_short | LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases |
| title_sort | lncrna kcnq1ot1 molecular mechanisms and pathogenic roles in human diseases |
| topic | Cell functions Human diseases KCNQ1OT1 Long non–coding RNA Regulatory ncRNA |
| url | http://www.sciencedirect.com/science/article/pii/S2352304221000957 |
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