Elaiophylin Inhibits Tumorigenesis of Human Uveal Melanoma by Suppressing Mitophagy and Inducing Oxidative Stress via Modulating SIRT1/FoxO3a Signaling

Elaiophylin Inhibits Tumorigenesis of Human Uveal Melanoma by Suppressing Mitophagy and Inducing Oxidative Stress via Modulating SIRT1/FoxO3a Signaling

Uveal melanoma (UM) is the most common primary intraocular tumor in adults, which is associated with poor prognosis. Up to 50% of UM patients develop metastasis. Therapeutics that have proven effective in cutaneous melanoma have little success in treating UM, possibly due to its low mutational burde...

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Bibliographic Details
Main Authors: Xue Zhu, Wenjun Zou, Xinmin Meng, Jiali Ji, Xun Wang, Hong Shu, Yuan Chen, Donghui Pan, Ke Wang, Fanfan Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
uveal melanoma
elaiophylin
mitophagy
oxidative stress
SIRT1/FoxO3a signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.788496/full

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