Exercise-induced bronchoconstriction in children with asthma: An observational cohort study
Background/purpose: The diagnosis of exercise-induced bronchoconstriction (EIB) was established by changes in lung function after exercise challenge. The prevalence of EIB and factors related to EIB were not fully described in children with asthma. The aim of this study was to investigate the preval...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Journal of Microbiology, Immunology and Infection |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118217301962 |
| _version_ | 1819229646793736192 |
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| author | Li-Lun Lin Shu-Jung Huang Liang-Shiou Ou Tsung-Chieh Yao Kuo-Chieh Tsao Kuo-Wei Yeh Jing-Long Huang |
| author_facet | Li-Lun Lin Shu-Jung Huang Liang-Shiou Ou Tsung-Chieh Yao Kuo-Chieh Tsao Kuo-Wei Yeh Jing-Long Huang |
| author_sort | Li-Lun Lin |
| collection | DOAJ |
| description | Background/purpose: The diagnosis of exercise-induced bronchoconstriction (EIB) was established by changes in lung function after exercise challenge. The prevalence of EIB and factors related to EIB were not fully described in children with asthma. The aim of this study was to investigate the prevalence and predictors of EIB in children with asthma. Methods: A total of 149 children with physician-diagnosed asthma above 5 years of age underwent standardized treadmill exercise challenge for EIB and methacholine challenge for airway hyper-responsiveness from October 2015 to December 2016. Results: EIB presented in 52.5% of children with asthma. Compared with children without EIB, there were more patients with atopic dermatitis in children with EIB (p = 0.038). Allergic to Dermatohagoides pteronyssinus and Dermatophagoides farinae were also found more in children with EIB (p = 0.045 and 0.048 respectively). Maximal decrease in forced expiratory volume in 1 s (FEV1) were highest in patients who were most sensitive to methacholine provocation (provocation concentration causing 20% fall in FEV1 [PC20] ≤ 1 mg/mL). Patients, who were more sensitive to methacholine challenge (with lower PC20 levels), develop EIB with more decline in FEV1 after exercise challenge (p = 0.038). Among patients with EIB, airflow limitation development in patient with methacholine-induced airway hyper-responsiveness was more abrupt and severe compared with patients without airway hyper-responsiveness (p = 0.045 and 0.033 respectively). Conclusion: EIB presented in 52.5% of children with asthma. The more severe methacholine-induced hyper-responsiveness, the higher prevalence of EIB as well as the severity. Keywords: Exercise-induced bronchoconstriction, Pediatric asthma, Exercise challenge, Airway hyperresponsiveness, Methacholine challenge |
| first_indexed | 2024-12-23T11:16:29Z |
| format | Article |
| id | doaj.art-9df78b88b03e46359edfafb7395163d5 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-12-23T11:16:29Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-9df78b88b03e46359edfafb7395163d52022-12-21T17:49:13ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822019-06-01523471479Exercise-induced bronchoconstriction in children with asthma: An observational cohort studyLi-Lun Lin0Shu-Jung Huang1Liang-Shiou Ou2Tsung-Chieh Yao3Kuo-Chieh Tsao4Kuo-Wei Yeh5Jing-Long Huang6Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, TaiwanDepartment of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Biotechnology & Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan; Corresponding author. Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Children's Hospital, 5, Fuxing St., Guishan Dist., Taoyuan City, 333, Taiwan. Fax: +886 3 328 8957.Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan; Corresponding author. Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Children's Hospital, 5, Fuxing St., Guishan Dist., Taoyuan City, 333, Taiwan. Fax: +886 3 328 8957.Background/purpose: The diagnosis of exercise-induced bronchoconstriction (EIB) was established by changes in lung function after exercise challenge. The prevalence of EIB and factors related to EIB were not fully described in children with asthma. The aim of this study was to investigate the prevalence and predictors of EIB in children with asthma. Methods: A total of 149 children with physician-diagnosed asthma above 5 years of age underwent standardized treadmill exercise challenge for EIB and methacholine challenge for airway hyper-responsiveness from October 2015 to December 2016. Results: EIB presented in 52.5% of children with asthma. Compared with children without EIB, there were more patients with atopic dermatitis in children with EIB (p = 0.038). Allergic to Dermatohagoides pteronyssinus and Dermatophagoides farinae were also found more in children with EIB (p = 0.045 and 0.048 respectively). Maximal decrease in forced expiratory volume in 1 s (FEV1) were highest in patients who were most sensitive to methacholine provocation (provocation concentration causing 20% fall in FEV1 [PC20] ≤ 1 mg/mL). Patients, who were more sensitive to methacholine challenge (with lower PC20 levels), develop EIB with more decline in FEV1 after exercise challenge (p = 0.038). Among patients with EIB, airflow limitation development in patient with methacholine-induced airway hyper-responsiveness was more abrupt and severe compared with patients without airway hyper-responsiveness (p = 0.045 and 0.033 respectively). Conclusion: EIB presented in 52.5% of children with asthma. The more severe methacholine-induced hyper-responsiveness, the higher prevalence of EIB as well as the severity. Keywords: Exercise-induced bronchoconstriction, Pediatric asthma, Exercise challenge, Airway hyperresponsiveness, Methacholine challengehttp://www.sciencedirect.com/science/article/pii/S1684118217301962 |
| spellingShingle | Li-Lun Lin Shu-Jung Huang Liang-Shiou Ou Tsung-Chieh Yao Kuo-Chieh Tsao Kuo-Wei Yeh Jing-Long Huang Exercise-induced bronchoconstriction in children with asthma: An observational cohort study Journal of Microbiology, Immunology and Infection |
| title | Exercise-induced bronchoconstriction in children with asthma: An observational cohort study |
| title_full | Exercise-induced bronchoconstriction in children with asthma: An observational cohort study |
| title_fullStr | Exercise-induced bronchoconstriction in children with asthma: An observational cohort study |
| title_full_unstemmed | Exercise-induced bronchoconstriction in children with asthma: An observational cohort study |
| title_short | Exercise-induced bronchoconstriction in children with asthma: An observational cohort study |
| title_sort | exercise induced bronchoconstriction in children with asthma an observational cohort study |
| url | http://www.sciencedirect.com/science/article/pii/S1684118217301962 |
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