Atomic force microscopy probing in the measurement of cell mechanics
Dimitrios Kirmizis, Stergios LogothetidisDepartment of Physics, Laboratory for Thin Films-Nanosystems and Nanometrology, Aristotle University, Thessaloniki, GreeceAbstract: Atomic force microscope (AFM) has been used incrementally over the last decade in cell biology. Beyond its usefulness in high r...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2010-03-01
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| Series: | International Journal of Nanomedicine |
| Online Access: | http://www.dovepress.com/atomic-force-microscopy-probing-in-the-measurement-of-cell-mechanics-a4112 |
| _version_ | 1818905786866204672 |
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| author | Dimitrios Kirmizis Stergios Logothetidis |
| author_facet | Dimitrios Kirmizis Stergios Logothetidis |
| author_sort | Dimitrios Kirmizis |
| collection | DOAJ |
| description | Dimitrios Kirmizis, Stergios LogothetidisDepartment of Physics, Laboratory for Thin Films-Nanosystems and Nanometrology, Aristotle University, Thessaloniki, GreeceAbstract: Atomic force microscope (AFM) has been used incrementally over the last decade in cell biology. Beyond its usefulness in high resolution imaging, AFM also has unique capabilities for probing the viscoelastic properties of living cells in culture and, even more, mapping the spatial distribution of cell mechanical properties, providing thus an indirect indicator of the structure and function of the underlying cytoskeleton and cell organelles. AFM measurements have boosted our understanding of cell mechanics in normal and diseased states and provide future potential in the study of disease pathophysiology and in the establishment of novel diagnostic and treatment options.Keywords: atomic force microscopy, cell mechanics, cell elastography, cell force spectroscopy |
| first_indexed | 2024-12-19T21:28:52Z |
| format | Article |
| id | doaj.art-9dfa35cfb47e41858f4674e933a2634d |
| institution | Directory Open Access Journal |
| issn | 1176-9114 1178-2013 |
| language | English |
| last_indexed | 2024-12-19T21:28:52Z |
| publishDate | 2010-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-9dfa35cfb47e41858f4674e933a2634d2022-12-21T20:05:01ZengDove Medical PressInternational Journal of Nanomedicine1176-91141178-20132010-03-012010default137145Atomic force microscopy probing in the measurement of cell mechanicsDimitrios KirmizisStergios LogothetidisDimitrios Kirmizis, Stergios LogothetidisDepartment of Physics, Laboratory for Thin Films-Nanosystems and Nanometrology, Aristotle University, Thessaloniki, GreeceAbstract: Atomic force microscope (AFM) has been used incrementally over the last decade in cell biology. Beyond its usefulness in high resolution imaging, AFM also has unique capabilities for probing the viscoelastic properties of living cells in culture and, even more, mapping the spatial distribution of cell mechanical properties, providing thus an indirect indicator of the structure and function of the underlying cytoskeleton and cell organelles. AFM measurements have boosted our understanding of cell mechanics in normal and diseased states and provide future potential in the study of disease pathophysiology and in the establishment of novel diagnostic and treatment options.Keywords: atomic force microscopy, cell mechanics, cell elastography, cell force spectroscopyhttp://www.dovepress.com/atomic-force-microscopy-probing-in-the-measurement-of-cell-mechanics-a4112 |
| spellingShingle | Dimitrios Kirmizis Stergios Logothetidis Atomic force microscopy probing in the measurement of cell mechanics International Journal of Nanomedicine |
| title | Atomic force microscopy probing in the measurement of cell mechanics |
| title_full | Atomic force microscopy probing in the measurement of cell mechanics |
| title_fullStr | Atomic force microscopy probing in the measurement of cell mechanics |
| title_full_unstemmed | Atomic force microscopy probing in the measurement of cell mechanics |
| title_short | Atomic force microscopy probing in the measurement of cell mechanics |
| title_sort | atomic force microscopy probing in the measurement of cell mechanics |
| url | http://www.dovepress.com/atomic-force-microscopy-probing-in-the-measurement-of-cell-mechanics-a4112 |
| work_keys_str_mv | AT dimitrioskirmizis atomicforcemicroscopyprobinginthemeasurementofcellmechanics AT stergioslogothetidis atomicforcemicroscopyprobinginthemeasurementofcellmechanics |