The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells
Neuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3′, 5′-cyclic monophosphate (cAMP), thus modulating cancer progress in different kind of tumours. As one of the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/1/311 |
| _version_ | 1797498204872245248 |
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| author | Zhengyin Gao Weng I Lei Leo Tsz On Lee |
| author_facet | Zhengyin Gao Weng I Lei Leo Tsz On Lee |
| author_sort | Zhengyin Gao |
| collection | DOAJ |
| description | Neuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3′, 5′-cyclic monophosphate (cAMP), thus modulating cancer progress in different kind of tumours. As one of the downstream effectors of cAMP, exchange proteins directly activated by cAMP (EPACs) play dual roles in cancer proliferation and metastasis. More evidence about the relationship between neuropeptides and EPAC pathways have been proposed for their potential role in cancer development; hence, this review focuses on the role of neuropeptide/GPCR system modulation of cAMP/EPACs pathways in cancers. The correlated downstream pathways between neuropeptides and EPACs in cancer cell proliferation, migration, and metastasis is discussed to glimmer the direction of future research. |
| first_indexed | 2024-03-10T03:30:06Z |
| format | Article |
| id | doaj.art-9dfa450f59fd4f398e3665f3605d174a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:30:06Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9dfa450f59fd4f398e3665f3605d174a2023-11-23T11:59:47ZengMDPI AGMolecules1420-30492022-01-0127131110.3390/molecules27010311The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer CellsZhengyin Gao0Weng I Lei1Leo Tsz On Lee2Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau, ChinaCancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau, ChinaCancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau, ChinaNeuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3′, 5′-cyclic monophosphate (cAMP), thus modulating cancer progress in different kind of tumours. As one of the downstream effectors of cAMP, exchange proteins directly activated by cAMP (EPACs) play dual roles in cancer proliferation and metastasis. More evidence about the relationship between neuropeptides and EPAC pathways have been proposed for their potential role in cancer development; hence, this review focuses on the role of neuropeptide/GPCR system modulation of cAMP/EPACs pathways in cancers. The correlated downstream pathways between neuropeptides and EPACs in cancer cell proliferation, migration, and metastasis is discussed to glimmer the direction of future research.https://www.mdpi.com/1420-3049/27/1/311G protein-coupled receptorexchange proteins directly activated by cAMP (EPAC)cAMPcancer |
| spellingShingle | Zhengyin Gao Weng I Lei Leo Tsz On Lee The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells Molecules G protein-coupled receptor exchange proteins directly activated by cAMP (EPAC) cAMP cancer |
| title | The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells |
| title_full | The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells |
| title_fullStr | The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells |
| title_full_unstemmed | The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells |
| title_short | The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells |
| title_sort | role of neuropeptide stimulated camp epacs signalling in cancer cells |
| topic | G protein-coupled receptor exchange proteins directly activated by cAMP (EPAC) cAMP cancer |
| url | https://www.mdpi.com/1420-3049/27/1/311 |
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