Neuron-Glia Interactions in Neurodevelopmental Disorders
Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity. Glial cells contribute to neuroinflammation and synaptic homeostasis, the latter being essential for maintaining the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/10/2176 |
| _version_ | 1797552432837820416 |
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| author | Yoo Sung Kim Juwon Choi Bo-Eun Yoon |
| author_facet | Yoo Sung Kim Juwon Choi Bo-Eun Yoon |
| author_sort | Yoo Sung Kim |
| collection | DOAJ |
| description | Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity. Glial cells contribute to neuroinflammation and synaptic homeostasis, the latter being essential for maintaining the physiological function of the central nervous system (CNS). In particular, glial cells undergo gliotransmission and regulate neuronal activity in tripartite synapses via ion channels (gap junction hemichannel, volume regulated anion channel, and bestrophin-1), receptors (for neurotransmitters and cytokines), or transporters (GLT-1, GLAST, and GATs) that are expressed on glial cell membranes. In this review, we propose that dysfunction in neuron-glia interactions may contribute to the pathogenesis of neurodevelopmental disorders. Understanding the mechanisms of neuron-glia interaction for synapse formation and maturation will contribute to the development of novel therapeutic targets of neurodevelopmental disorders. |
| first_indexed | 2024-03-10T16:00:58Z |
| format | Article |
| id | doaj.art-9dfafc675b3a40548938024ec00c80e3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T16:00:58Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9dfafc675b3a40548938024ec00c80e32023-11-20T15:19:41ZengMDPI AGCells2073-44092020-09-01910217610.3390/cells9102176Neuron-Glia Interactions in Neurodevelopmental DisordersYoo Sung Kim0Juwon Choi1Bo-Eun Yoon2Department of Molecular Biology, Dankook University, Cheonan 31116, KoreaDepartment of Molecular Biology, Dankook University, Cheonan 31116, KoreaDepartment of Molecular Biology, Dankook University, Cheonan 31116, KoreaRecent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity. Glial cells contribute to neuroinflammation and synaptic homeostasis, the latter being essential for maintaining the physiological function of the central nervous system (CNS). In particular, glial cells undergo gliotransmission and regulate neuronal activity in tripartite synapses via ion channels (gap junction hemichannel, volume regulated anion channel, and bestrophin-1), receptors (for neurotransmitters and cytokines), or transporters (GLT-1, GLAST, and GATs) that are expressed on glial cell membranes. In this review, we propose that dysfunction in neuron-glia interactions may contribute to the pathogenesis of neurodevelopmental disorders. Understanding the mechanisms of neuron-glia interaction for synapse formation and maturation will contribute to the development of novel therapeutic targets of neurodevelopmental disorders.https://www.mdpi.com/2073-4409/9/10/2176neurodevelopmental disorderneuron-glia interactionsASDADHDepilepsy |
| spellingShingle | Yoo Sung Kim Juwon Choi Bo-Eun Yoon Neuron-Glia Interactions in Neurodevelopmental Disorders Cells neurodevelopmental disorder neuron-glia interactions ASD ADHD epilepsy |
| title | Neuron-Glia Interactions in Neurodevelopmental Disorders |
| title_full | Neuron-Glia Interactions in Neurodevelopmental Disorders |
| title_fullStr | Neuron-Glia Interactions in Neurodevelopmental Disorders |
| title_full_unstemmed | Neuron-Glia Interactions in Neurodevelopmental Disorders |
| title_short | Neuron-Glia Interactions in Neurodevelopmental Disorders |
| title_sort | neuron glia interactions in neurodevelopmental disorders |
| topic | neurodevelopmental disorder neuron-glia interactions ASD ADHD epilepsy |
| url | https://www.mdpi.com/2073-4409/9/10/2176 |
| work_keys_str_mv | AT yoosungkim neurongliainteractionsinneurodevelopmentaldisorders AT juwonchoi neurongliainteractionsinneurodevelopmentaldisorders AT boeunyoon neurongliainteractionsinneurodevelopmentaldisorders |