Asymptomatic intracranial arterial stenosis and metabolic syndrome: the APAC study.
PURPOSE: The metabolic syndrome (MetS) is a major risk factor for cardiovascular diseases. We investigated potential associations between MetS and asymptomatic intracranial arterial stenosis (ICAS) in a general population. METHODS: The community-based "Asymptomatic Polyvascular Abnormalities in...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4251973?pdf=render |
| _version_ | 1818953579808948224 |
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| author | Anxin Wang Zhaoxia Li Yanxia Luo Xiaoxue Liu Xiuhua Guo Shouling Wu Xingquan Zhao Jost B Jonas |
| author_facet | Anxin Wang Zhaoxia Li Yanxia Luo Xiaoxue Liu Xiuhua Guo Shouling Wu Xingquan Zhao Jost B Jonas |
| author_sort | Anxin Wang |
| collection | DOAJ |
| description | PURPOSE: The metabolic syndrome (MetS) is a major risk factor for cardiovascular diseases. We investigated potential associations between MetS and asymptomatic intracranial arterial stenosis (ICAS) in a general population. METHODS: The community-based "Asymptomatic Polyvascular Abnormalities in Community Study" examined asymptomatic polyvascular abnormalities in a Chinese population aged 40+ years without history of stroke and coronary heart disease. MetS was defined by the International Diabetes Federation criteria. Asymptomatic ICAS was diagnosed by transcranial color-coded Doppler sonography. RESULTS: Out of 5393 study participants, asymptomatic ICAS was detected in 713 (13.2%) participants, and MetS in 1323 (24.5%) individuals. Prevalence of asymptomatic ICAS increased significantly from 7.5% to 24.2% with increasing number of MetS components. After adjusting for age, gender, physical activity, body mass index, low-density lipoprotein cholesterol and high-sensitivity C-reactive protein, MetS was significantly associated with asymptomatic ICAS (OR: 1.50; 95%CI: 1.23,1.83). Compared with the subgroup without MetS, the ORs for asymptomatic ICAS increased (P<0.0001) for each of 5 components of MetS from 1.71 (95%CI: 1.27,2.30), to 2.20 (95%CI: 1.63,2.98), 2.79 (95CI: 2.01,3.88), 3.08 (95%CI: 2.11,4.51) and 4.27 (95%CI: 2.22,8.20). CONCLUSIONS: In multivariate analysis, MetS was an independent and additional factor associated with asymptomatic ICAS. Study participants with 5 MetS components had a 4 times higher risk of asymptomatic ICAS than participants with no MetS component. |
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| id | doaj.art-9dfd1fce12f2418ea7a54f8578360e47 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T10:08:31Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9dfd1fce12f2418ea7a54f8578360e472022-12-21T19:44:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11320510.1371/journal.pone.0113205Asymptomatic intracranial arterial stenosis and metabolic syndrome: the APAC study.Anxin WangZhaoxia LiYanxia LuoXiaoxue LiuXiuhua GuoShouling WuXingquan ZhaoJost B JonasPURPOSE: The metabolic syndrome (MetS) is a major risk factor for cardiovascular diseases. We investigated potential associations between MetS and asymptomatic intracranial arterial stenosis (ICAS) in a general population. METHODS: The community-based "Asymptomatic Polyvascular Abnormalities in Community Study" examined asymptomatic polyvascular abnormalities in a Chinese population aged 40+ years without history of stroke and coronary heart disease. MetS was defined by the International Diabetes Federation criteria. Asymptomatic ICAS was diagnosed by transcranial color-coded Doppler sonography. RESULTS: Out of 5393 study participants, asymptomatic ICAS was detected in 713 (13.2%) participants, and MetS in 1323 (24.5%) individuals. Prevalence of asymptomatic ICAS increased significantly from 7.5% to 24.2% with increasing number of MetS components. After adjusting for age, gender, physical activity, body mass index, low-density lipoprotein cholesterol and high-sensitivity C-reactive protein, MetS was significantly associated with asymptomatic ICAS (OR: 1.50; 95%CI: 1.23,1.83). Compared with the subgroup without MetS, the ORs for asymptomatic ICAS increased (P<0.0001) for each of 5 components of MetS from 1.71 (95%CI: 1.27,2.30), to 2.20 (95%CI: 1.63,2.98), 2.79 (95CI: 2.01,3.88), 3.08 (95%CI: 2.11,4.51) and 4.27 (95%CI: 2.22,8.20). CONCLUSIONS: In multivariate analysis, MetS was an independent and additional factor associated with asymptomatic ICAS. Study participants with 5 MetS components had a 4 times higher risk of asymptomatic ICAS than participants with no MetS component.http://europepmc.org/articles/PMC4251973?pdf=render |
| spellingShingle | Anxin Wang Zhaoxia Li Yanxia Luo Xiaoxue Liu Xiuhua Guo Shouling Wu Xingquan Zhao Jost B Jonas Asymptomatic intracranial arterial stenosis and metabolic syndrome: the APAC study. PLoS ONE |
| title | Asymptomatic intracranial arterial stenosis and metabolic syndrome: the APAC study. |
| title_full | Asymptomatic intracranial arterial stenosis and metabolic syndrome: the APAC study. |
| title_fullStr | Asymptomatic intracranial arterial stenosis and metabolic syndrome: the APAC study. |
| title_full_unstemmed | Asymptomatic intracranial arterial stenosis and metabolic syndrome: the APAC study. |
| title_short | Asymptomatic intracranial arterial stenosis and metabolic syndrome: the APAC study. |
| title_sort | asymptomatic intracranial arterial stenosis and metabolic syndrome the apac study |
| url | http://europepmc.org/articles/PMC4251973?pdf=render |
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