Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Human peripheral neuropathies are poorly understood, and the availability of experimental models limits further research. The PeriTox test uses immature dorsal root ganglia (DRG)-like neurons, derived from induced pluripotent stem cells (iPSC), to assess cell death and neurite damage. Here, we explo...

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Bibliographic Details
Main Authors: Anna-Katharina Holzer, Ilinca Suciu, Christiaan Karreman, Thomas Goj, Marcel Leist
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
nociceptors
purinergic receptor P2X3
peripheral nervous system diseases
bortezomib
proteasome inhibitors
Online Access:https://www.mdpi.com/1422-0067/23/7/3734

Internet

https://www.mdpi.com/1422-0067/23/7/3734

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