Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score
Abstract Background Human herpesviruses (HHVs) are responsible for a significant number of clinical manifestations in systemic lupus erythematous (SLE) patients. The aim of this study was to determine the frequency of active HHV infections in SLE patients and correlating them with disease activity....
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BMC
2020-08-01
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| Series: | Advances in Rheumatology |
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| Online Access: | http://link.springer.com/article/10.1186/s42358-020-00144-6 |
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| author | Alex Domingos dos Reis Cristiane Mudinutti Murilo de Freitas Peigo Lucas Lopes Leon Lilian Tereza Lavras Costallat Claudio Lucio Rossi Sandra Cecília Botelho Costa Sandra Helena Alves Bonon |
| author_facet | Alex Domingos dos Reis Cristiane Mudinutti Murilo de Freitas Peigo Lucas Lopes Leon Lilian Tereza Lavras Costallat Claudio Lucio Rossi Sandra Cecília Botelho Costa Sandra Helena Alves Bonon |
| author_sort | Alex Domingos dos Reis |
| collection | DOAJ |
| description | Abstract Background Human herpesviruses (HHVs) are responsible for a significant number of clinical manifestations in systemic lupus erythematous (SLE) patients. The aim of this study was to determine the frequency of active HHV infections in SLE patients and correlating them with disease activity. Methods Serum samples were collected from 71 SLE patients and their DNAs were extracted and analyzed to detect HHV-DNA viruses using the nucleic acid amplification technique. Results Fifteen out of the 71 (21.1%) patients tested positive for the HHV-DNA virus. Of them, 11/15 HHV-DNA-positive patients (73.3%) had SLE activity index (SLEDAI – Systemic Lupus Erythematosus Disease Activity Index) ≥8 (p = 0.0001). Active HCMV infection was the mostly frequently observed infection, occurring in 6/15 patients (40%). The frequencies of other active viral infections were 22% for HSV-1, 16.7% for HHV-7, and 5.5% for HSV-2. Viral coinfection (two or more viruses detected in the same sample) occurred in three patients (16.7%). Active HHV infections in SLE patients are more frequent in those with active SLE (≥8), who is at high risk of HHV reactivation and HCMV disease. Conclusion Viral surveillance is important to identify active HHV infections that can cause clinical symptoms and other complication in SLE patients. |
| first_indexed | 2024-12-21T19:48:37Z |
| format | Article |
| id | doaj.art-9e020e8d154e48298809cc88c2339570 |
| institution | Directory Open Access Journal |
| issn | 2523-3106 |
| language | English |
| last_indexed | 2024-12-21T19:48:37Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj.art-9e020e8d154e48298809cc88c23395702022-12-21T18:52:15ZengBMCAdvances in Rheumatology2523-31062020-08-016011710.1186/s42358-020-00144-6Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI scoreAlex Domingos dos Reis0Cristiane Mudinutti1Murilo de Freitas Peigo2Lucas Lopes Leon3Lilian Tereza Lavras Costallat4Claudio Lucio Rossi5Sandra Cecília Botelho Costa6Sandra Helena Alves Bonon7Laboratory of Virology, School of Medical Sciences, State University of Campinas (UNICAMP)Laboratory of Virology, School of Medical Sciences, State University of Campinas (UNICAMP)Laboratory of Virology, School of Medical Sciences, State University of Campinas (UNICAMP)Laboratory of Virology, School of Medical Sciences, State University of Campinas (UNICAMP)Department of Internal Medicine, Discipline of Rheumatology, School of Medical Sciences, State University of Campinas (UNICAMP)Department of Clinical Pathology, School of Medical Sciences, State University of Campinas (UNICAMP)Laboratory of Virology, School of Medical Sciences, State University of Campinas (UNICAMP)Laboratory of Virology, School of Medical Sciences, State University of Campinas (UNICAMP)Abstract Background Human herpesviruses (HHVs) are responsible for a significant number of clinical manifestations in systemic lupus erythematous (SLE) patients. The aim of this study was to determine the frequency of active HHV infections in SLE patients and correlating them with disease activity. Methods Serum samples were collected from 71 SLE patients and their DNAs were extracted and analyzed to detect HHV-DNA viruses using the nucleic acid amplification technique. Results Fifteen out of the 71 (21.1%) patients tested positive for the HHV-DNA virus. Of them, 11/15 HHV-DNA-positive patients (73.3%) had SLE activity index (SLEDAI – Systemic Lupus Erythematosus Disease Activity Index) ≥8 (p = 0.0001). Active HCMV infection was the mostly frequently observed infection, occurring in 6/15 patients (40%). The frequencies of other active viral infections were 22% for HSV-1, 16.7% for HHV-7, and 5.5% for HSV-2. Viral coinfection (two or more viruses detected in the same sample) occurred in three patients (16.7%). Active HHV infections in SLE patients are more frequent in those with active SLE (≥8), who is at high risk of HHV reactivation and HCMV disease. Conclusion Viral surveillance is important to identify active HHV infections that can cause clinical symptoms and other complication in SLE patients.http://link.springer.com/article/10.1186/s42358-020-00144-6HerpesviridaeSystemic lupus erythematosusPolymerase chain reaction |
| spellingShingle | Alex Domingos dos Reis Cristiane Mudinutti Murilo de Freitas Peigo Lucas Lopes Leon Lilian Tereza Lavras Costallat Claudio Lucio Rossi Sandra Cecília Botelho Costa Sandra Helena Alves Bonon Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score Advances in Rheumatology Herpesviridae Systemic lupus erythematosus Polymerase chain reaction |
| title | Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score |
| title_full | Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score |
| title_fullStr | Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score |
| title_full_unstemmed | Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score |
| title_short | Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score |
| title_sort | active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the sledai score |
| topic | Herpesviridae Systemic lupus erythematosus Polymerase chain reaction |
| url | http://link.springer.com/article/10.1186/s42358-020-00144-6 |
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