Research Progress on the Molecular Mechanism of Polymorph Nucleation in Solution: A Perspective from Research Mentality and Technique
Based on the importance of polymorphic regulation, the molecular mechanism of nucleation has been widely concerned. This review begins by introducing the development and limitations of nucleation theory for organic small molecule crystals, followed by a summary of the general research mentality adop...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Crystals |
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| Online Access: | https://www.mdpi.com/2073-4352/13/8/1206 |
| _version_ | 1797585059457269760 |
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| author | Peng Shi Ying Han Zhenxing Zhu Junbo Gong |
| author_facet | Peng Shi Ying Han Zhenxing Zhu Junbo Gong |
| author_sort | Peng Shi |
| collection | DOAJ |
| description | Based on the importance of polymorphic regulation, the molecular mechanism of nucleation has been widely concerned. This review begins by introducing the development and limitations of nucleation theory for organic small molecule crystals, followed by a summary of the general research mentality adopted by current researchers. Moreover, the progress of the molecular mechanism of polymorphic nucleation and its application to the regulation of crystal forms are discussed. In addition, the development of scientific tools for the study of the molecular mechanism of polymorphic nucleation is also summarized, including experimental characterization and computational simulation, providing reference for relevant researchers. Finally, according to the main defects of current research and research ideas, research models and development directions of prospects and recommendations are put forward. |
| first_indexed | 2024-03-11T00:01:30Z |
| format | Article |
| id | doaj.art-9e02b7655469476f9f5cb705a81694cf |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-03-11T00:01:30Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-9e02b7655469476f9f5cb705a81694cf2023-11-19T00:44:52ZengMDPI AGCrystals2073-43522023-08-01138120610.3390/cryst13081206Research Progress on the Molecular Mechanism of Polymorph Nucleation in Solution: A Perspective from Research Mentality and TechniquePeng Shi0Ying Han1Zhenxing Zhu2Junbo Gong3SINOPEC Research Institute of Petroleum Processing Co., Ltd., Beijing 100083, ChinaSINOPEC Research Institute of Petroleum Processing Co., Ltd., Beijing 100083, ChinaSINOPEC Research Institute of Petroleum Processing Co., Ltd., Beijing 100083, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaBased on the importance of polymorphic regulation, the molecular mechanism of nucleation has been widely concerned. This review begins by introducing the development and limitations of nucleation theory for organic small molecule crystals, followed by a summary of the general research mentality adopted by current researchers. Moreover, the progress of the molecular mechanism of polymorphic nucleation and its application to the regulation of crystal forms are discussed. In addition, the development of scientific tools for the study of the molecular mechanism of polymorphic nucleation is also summarized, including experimental characterization and computational simulation, providing reference for relevant researchers. Finally, according to the main defects of current research and research ideas, research models and development directions of prospects and recommendations are put forward.https://www.mdpi.com/2073-4352/13/8/1206crystallizationphase changepolymorphnucleationmolecular routemechanism |
| spellingShingle | Peng Shi Ying Han Zhenxing Zhu Junbo Gong Research Progress on the Molecular Mechanism of Polymorph Nucleation in Solution: A Perspective from Research Mentality and Technique Crystals crystallization phase change polymorph nucleation molecular route mechanism |
| title | Research Progress on the Molecular Mechanism of Polymorph Nucleation in Solution: A Perspective from Research Mentality and Technique |
| title_full | Research Progress on the Molecular Mechanism of Polymorph Nucleation in Solution: A Perspective from Research Mentality and Technique |
| title_fullStr | Research Progress on the Molecular Mechanism of Polymorph Nucleation in Solution: A Perspective from Research Mentality and Technique |
| title_full_unstemmed | Research Progress on the Molecular Mechanism of Polymorph Nucleation in Solution: A Perspective from Research Mentality and Technique |
| title_short | Research Progress on the Molecular Mechanism of Polymorph Nucleation in Solution: A Perspective from Research Mentality and Technique |
| title_sort | research progress on the molecular mechanism of polymorph nucleation in solution a perspective from research mentality and technique |
| topic | crystallization phase change polymorph nucleation molecular route mechanism |
| url | https://www.mdpi.com/2073-4352/13/8/1206 |
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