Role of autophagy in cancer-associated fibroblast activation, signaling and metabolic reprograming
Tumors not only consist of cancerous cells, but they also harbor several normal-like cell types and non-cellular components. cancer-associated fibroblasts (CAFs) are one of these cellular components that are found predominantly in the tumor stroma. Autophagy is an intracellular degradation and quali...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1274682/full |
| _version_ | 1797367767216685056 |
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| author | Dyana Sari Devrim Gozuacik Devrim Gozuacik Devrim Gozuacik Yunus Akkoc |
| author_facet | Dyana Sari Devrim Gozuacik Devrim Gozuacik Devrim Gozuacik Yunus Akkoc |
| author_sort | Dyana Sari |
| collection | DOAJ |
| description | Tumors not only consist of cancerous cells, but they also harbor several normal-like cell types and non-cellular components. cancer-associated fibroblasts (CAFs) are one of these cellular components that are found predominantly in the tumor stroma. Autophagy is an intracellular degradation and quality control mechanism, and recent studies provided evidence that autophagy played a critical role in CAF formation, metabolic reprograming and tumor-stroma crosstalk. Therefore, shedding light on the autophagy and its role in CAF biology might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the exploitation of more efficient cancer diagnosis and treatment. Here, we provide an overview about the involvement of autophagy in CAF-related pathways, including transdifferentiation and activation of CAFs, and further discuss the implications of targeting tumor stroma as a treatment option. |
| first_indexed | 2024-03-08T17:21:58Z |
| format | Article |
| id | doaj.art-9e035d6a87014efdb2eb06229b422d34 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-08T17:21:58Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9e035d6a87014efdb2eb06229b422d342024-01-03T04:31:30ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-01-011110.3389/fcell.2023.12746821274682Role of autophagy in cancer-associated fibroblast activation, signaling and metabolic reprogramingDyana Sari0Devrim Gozuacik1Devrim Gozuacik2Devrim Gozuacik3Yunus Akkoc4Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, TürkiyeKoç University Research Center for Translational Medicine (KUTTAM), Istanbul, TürkiyeDepartment of Medical Biology, School of Medicine, Koç University, Istanbul, TürkiyeDepartment of Biotechnology, SUNUM Nanotechnology Research and Application Center, Istanbul, TürkiyeKoç University Research Center for Translational Medicine (KUTTAM), Istanbul, TürkiyeTumors not only consist of cancerous cells, but they also harbor several normal-like cell types and non-cellular components. cancer-associated fibroblasts (CAFs) are one of these cellular components that are found predominantly in the tumor stroma. Autophagy is an intracellular degradation and quality control mechanism, and recent studies provided evidence that autophagy played a critical role in CAF formation, metabolic reprograming and tumor-stroma crosstalk. Therefore, shedding light on the autophagy and its role in CAF biology might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the exploitation of more efficient cancer diagnosis and treatment. Here, we provide an overview about the involvement of autophagy in CAF-related pathways, including transdifferentiation and activation of CAFs, and further discuss the implications of targeting tumor stroma as a treatment option.https://www.frontiersin.org/articles/10.3389/fcell.2023.1274682/fullcancer-associated fibroblasts (CAFs)autophagytumor microenvironment (TME)fibroblast transdifferentiationcancer |
| spellingShingle | Dyana Sari Devrim Gozuacik Devrim Gozuacik Devrim Gozuacik Yunus Akkoc Role of autophagy in cancer-associated fibroblast activation, signaling and metabolic reprograming Frontiers in Cell and Developmental Biology cancer-associated fibroblasts (CAFs) autophagy tumor microenvironment (TME) fibroblast transdifferentiation cancer |
| title | Role of autophagy in cancer-associated fibroblast activation, signaling and metabolic reprograming |
| title_full | Role of autophagy in cancer-associated fibroblast activation, signaling and metabolic reprograming |
| title_fullStr | Role of autophagy in cancer-associated fibroblast activation, signaling and metabolic reprograming |
| title_full_unstemmed | Role of autophagy in cancer-associated fibroblast activation, signaling and metabolic reprograming |
| title_short | Role of autophagy in cancer-associated fibroblast activation, signaling and metabolic reprograming |
| title_sort | role of autophagy in cancer associated fibroblast activation signaling and metabolic reprograming |
| topic | cancer-associated fibroblasts (CAFs) autophagy tumor microenvironment (TME) fibroblast transdifferentiation cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1274682/full |
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