Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice

Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice

Obesity is one of the most significant risk factors for knee osteoarthritis. However, therapeutic strategies to prevent or treat obesity-associated osteoarthritis are limited because of uncertainty about the etiology of disease, particularly with regard to metabolic factors. High-fat-diet-induced ob...

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Bibliographic Details
Main Authors: Elise L. Donovan, Erika Barboza Prado Lopes, Albert Batushansky, Mike Kinter, Timothy M. Griffin
Format: Article
Language:English
Published: The Company of Biologists 2018-09-01
Series:Disease Models & Mechanisms
Subjects:
Osteoarthritis
Obesity
Cartilage
Metabolism
High-fat diet
Mouse
Online Access:http://dmm.biologists.org/content/11/9/dmm034827

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