Systemic toxicity induced by aggregated layered double hydroxide nanoparticles
Mina Yan, Chanzhen Yang, Binyao Huang, Zeqian Huang, Liangfeng Huang, Xuefei Zhang, Chunshun Zhao School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou Higher Education Mega Center, Guangzhou, China Abstract: Layered double hydroxide (LDH) nanoparticles are emerging as one of the pr...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-10-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/systemic-toxicity-induced-by-aggregated-layered-double-hydroxide-nanop-peer-reviewed-article-IJN |
| _version_ | 1819015793534304256 |
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| author | Yan M Yang C Huang B Huang Z Huang L Zhang X Zhao C |
| author_facet | Yan M Yang C Huang B Huang Z Huang L Zhang X Zhao C |
| author_sort | Yan M |
| collection | DOAJ |
| description | Mina Yan, Chanzhen Yang, Binyao Huang, Zeqian Huang, Liangfeng Huang, Xuefei Zhang, Chunshun Zhao School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou Higher Education Mega Center, Guangzhou, China Abstract: Layered double hydroxide (LDH) nanoparticles are emerging as one of the promising nanomaterials for biomedical applications, but their systemic toxicity in vivo has received little attention. In the present study, the effects of inorganic nanoparticle aggregation on their systemic toxicity were examined. Remarkably, aggregation was observed after the mixing of naked LDH nanoparticles with saline or erythrocytes. Significant accumulation of the naked LDH nanoparticles in the lungs of mice was detected 1 h after intravenous administration, and the survival rate of mice was 0% after 6 repeated injections. Furthermore, flocculent precipitates in the alveoli and congestion in the lung interstitium were observed in the dead mice. However, lipid membrane-coated LDH nanoparticles would not form aggregates and could be injected intravenously >6 times without causing death. These findings suggested that repeated injections of LDH were lethal even at low dose (30 mg/kg), and lipid membrane coating can be considered as an approach for reducing this risk. Keywords: inorganic nanoparticles, aggregation, erythrocyte aggregation, repeated intravenous injection, pulmonary embolism, sudden death |
| first_indexed | 2024-12-21T02:37:23Z |
| format | Article |
| id | doaj.art-9e0450cf0acf4596b149f15e749ca21a |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-21T02:37:23Z |
| publishDate | 2017-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-9e0450cf0acf4596b149f15e749ca21a2022-12-21T19:18:46ZengDove Medical PressInternational Journal of Nanomedicine1178-20132017-10-01Volume 127183719534979Systemic toxicity induced by aggregated layered double hydroxide nanoparticlesYan MYang CHuang BHuang ZHuang LZhang XZhao CMina Yan, Chanzhen Yang, Binyao Huang, Zeqian Huang, Liangfeng Huang, Xuefei Zhang, Chunshun Zhao School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou Higher Education Mega Center, Guangzhou, China Abstract: Layered double hydroxide (LDH) nanoparticles are emerging as one of the promising nanomaterials for biomedical applications, but their systemic toxicity in vivo has received little attention. In the present study, the effects of inorganic nanoparticle aggregation on their systemic toxicity were examined. Remarkably, aggregation was observed after the mixing of naked LDH nanoparticles with saline or erythrocytes. Significant accumulation of the naked LDH nanoparticles in the lungs of mice was detected 1 h after intravenous administration, and the survival rate of mice was 0% after 6 repeated injections. Furthermore, flocculent precipitates in the alveoli and congestion in the lung interstitium were observed in the dead mice. However, lipid membrane-coated LDH nanoparticles would not form aggregates and could be injected intravenously >6 times without causing death. These findings suggested that repeated injections of LDH were lethal even at low dose (30 mg/kg), and lipid membrane coating can be considered as an approach for reducing this risk. Keywords: inorganic nanoparticles, aggregation, erythrocyte aggregation, repeated intravenous injection, pulmonary embolism, sudden deathhttps://www.dovepress.com/systemic-toxicity-induced-by-aggregated-layered-double-hydroxide-nanop-peer-reviewed-article-IJNinorganic nanoparticlesaggregationsystemic toxicitylayered double hydroxide |
| spellingShingle | Yan M Yang C Huang B Huang Z Huang L Zhang X Zhao C Systemic toxicity induced by aggregated layered double hydroxide nanoparticles International Journal of Nanomedicine inorganic nanoparticles aggregation systemic toxicity layered double hydroxide |
| title | Systemic toxicity induced by aggregated layered double hydroxide nanoparticles |
| title_full | Systemic toxicity induced by aggregated layered double hydroxide nanoparticles |
| title_fullStr | Systemic toxicity induced by aggregated layered double hydroxide nanoparticles |
| title_full_unstemmed | Systemic toxicity induced by aggregated layered double hydroxide nanoparticles |
| title_short | Systemic toxicity induced by aggregated layered double hydroxide nanoparticles |
| title_sort | systemic toxicity induced by aggregated layered double hydroxide nanoparticles |
| topic | inorganic nanoparticles aggregation systemic toxicity layered double hydroxide |
| url | https://www.dovepress.com/systemic-toxicity-induced-by-aggregated-layered-double-hydroxide-nanop-peer-reviewed-article-IJN |
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