Regulation of PCSK9 Expression and Function: Mechanisms and Therapeutic Implications

Regulation of PCSK9 Expression and Function: Mechanisms and Therapeutic Implications

Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes degradation of low-density lipoprotein receptor (LDLR) and plays a central role in regulating plasma levels of LDL cholesterol levels, lipoprotein(a) and triglyceride-rich lipoproteins, increasing the risk of cardiovascular disease. Addi...

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Bibliographic Details
Main Authors: Xiao-dan Xia, Zhong-sheng Peng, Hong-mei Gu, Maggie Wang, Gui-qing Wang, Da-wei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
lipid metabolism
cardiovascular disease
atherosclerosis
cancer immunotherapy
PCSK9
LDL receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.764038/full

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