Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property [v1; ref status: indexed, http://f1000r.es/15s]
“Let food be thy medicine and medicine be thy food” was quoted by Hippocrates more than two thousand years ago and since ancient times the health benefits of different natural agents have been exploited. In modern research, the disease preventive benefits of many such natural agents, particularly di...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2013-06-01
|
| Series: | F1000Research |
| Subjects: | |
| Online Access: | http://f1000research.com/articles/2-135/v1 |
| _version_ | 1819171505985028096 |
|---|---|
| author | Asfar S Azmi Fazlul H Sarkar SM Hadi |
| author_facet | Asfar S Azmi Fazlul H Sarkar SM Hadi |
| author_sort | Asfar S Azmi |
| collection | DOAJ |
| description | “Let food be thy medicine and medicine be thy food” was quoted by Hippocrates more than two thousand years ago and since ancient times the health benefits of different natural agents have been exploited. In modern research, the disease preventive benefits of many such natural agents, particularly dietary compounds and their derivatives, has been attributed to their well recognized activity as the regulators of redox state of the cell. Nevertheless, most of these studies have focused on their antioxidant activity. A large body of evidence indicates that a major fraction of these agents can elicit pro-oxidant (radical generating) behavior which has been linked to their anti-cancer effects. This editorial provides an overview of the under-appreciated pro-oxidant activity of natural products, with a special focus on their ability to generate reactive oxygen species in the presence of transition metal ions, and discusses their possible use as cancer chemotherapeutic agents. |
| first_indexed | 2024-12-22T19:52:22Z |
| format | Article |
| id | doaj.art-9e06ad470e9b406f823f718ace532726 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-22T19:52:22Z |
| publishDate | 2013-06-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-9e06ad470e9b406f823f718ace5327262022-12-21T18:14:30ZengF1000 Research LtdF1000Research2046-14022013-06-01210.12688/f1000research.2-135.v11504Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property [v1; ref status: indexed, http://f1000r.es/15s]Asfar S Azmi0Fazlul H Sarkar1SM Hadi2Department of Pathology, Wayne State University School of Medicine, Detroit MI, 48201, USADepartment of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit MI, 48201, USADepartment of Biochemistry, Aligarh Muslim University, Aligarh, 202002, India“Let food be thy medicine and medicine be thy food” was quoted by Hippocrates more than two thousand years ago and since ancient times the health benefits of different natural agents have been exploited. In modern research, the disease preventive benefits of many such natural agents, particularly dietary compounds and their derivatives, has been attributed to their well recognized activity as the regulators of redox state of the cell. Nevertheless, most of these studies have focused on their antioxidant activity. A large body of evidence indicates that a major fraction of these agents can elicit pro-oxidant (radical generating) behavior which has been linked to their anti-cancer effects. This editorial provides an overview of the under-appreciated pro-oxidant activity of natural products, with a special focus on their ability to generate reactive oxygen species in the presence of transition metal ions, and discusses their possible use as cancer chemotherapeutic agents.http://f1000research.com/articles/2-135/v1Cancer Therapeutics |
| spellingShingle | Asfar S Azmi Fazlul H Sarkar SM Hadi Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property [v1; ref status: indexed, http://f1000r.es/15s] F1000Research Cancer Therapeutics |
| title | Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property [v1; ref status: indexed, http://f1000r.es/15s] |
| title_full | Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property [v1; ref status: indexed, http://f1000r.es/15s] |
| title_fullStr | Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property [v1; ref status: indexed, http://f1000r.es/15s] |
| title_full_unstemmed | Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property [v1; ref status: indexed, http://f1000r.es/15s] |
| title_short | Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property [v1; ref status: indexed, http://f1000r.es/15s] |
| title_sort | pro oxidant activity of dietary chemopreventive agents an under appreciated anti cancer property v1 ref status indexed http f1000r es 15s |
| topic | Cancer Therapeutics |
| url | http://f1000research.com/articles/2-135/v1 |
| work_keys_str_mv | AT asfarsazmi prooxidantactivityofdietarychemopreventiveagentsanunderappreciatedanticancerpropertyv1refstatusindexedhttpf1000res15s AT fazlulhsarkar prooxidantactivityofdietarychemopreventiveagentsanunderappreciatedanticancerpropertyv1refstatusindexedhttpf1000res15s AT smhadi prooxidantactivityofdietarychemopreventiveagentsanunderappreciatedanticancerpropertyv1refstatusindexedhttpf1000res15s |