Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study
IntroductionCraniopharyngioma is a rare brain tumour. Despite being histologically benign, it behaves aggressively and is often difficult to manage. Descriptive epidemiological data on the tumour is lacking in sub-Saharan Africa, and there is none for Zimbabwe. The tumour usually has a cystic compon...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1026926/full |
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| author | Luxwell Jokonya Tariro Lavender Mduluza-Jokonya Ignatius Esene Garikai Mwale Nqobile Sindiswa Thango Takafira Mduluza Thajasvarie Naicker |
| author_facet | Luxwell Jokonya Tariro Lavender Mduluza-Jokonya Ignatius Esene Garikai Mwale Nqobile Sindiswa Thango Takafira Mduluza Thajasvarie Naicker |
| author_sort | Luxwell Jokonya |
| collection | DOAJ |
| description | IntroductionCraniopharyngioma is a rare brain tumour. Despite being histologically benign, it behaves aggressively and is often difficult to manage. Descriptive epidemiological data on the tumour is lacking in sub-Saharan Africa, and there is none for Zimbabwe. The tumour usually has a cystic component that has been raising interest in the past decade. Few studies have looked at the biochemical composition thereof. This study aims to give a landscape view of craniopharyngiomas (CPs) in Zimbabwe and then profile the biochemical properties of the cystic component of paediatric adamantinomatous craniopharyngioma.MethodologyA prospective cohort study was done in Zimbabwe over a 2-year period to study the epidemiological distribution of craniopharyngioma and examine the biochemical composition of adamantinomatous craniopharyngioma cystic fluid in the paediatric population. Fifteen patients were recruited who had craniopharyngiomas, and of those, nine paediatric adamantinomatous craniopharyngiomas had fluid analysed for biochemical components. SPSS statistical package was used to analyse the data. Descriptive statistics were used for epidemiological data.ResultsThe incidence of CP was calculated to be 0.53 per million person-years. Incidence among the paediatric population 0–14 years was 1.2 per 100,000 person-years. Several biological components were found to be elevated significantly compared to serum and cerebral spinal fluid (CSF). These are sodium, potassium, urea, alkaline phosphatase, phosphate, magnesium, albumin, gamma-glutamyl transferase, calcium, low-density lipids, and glucose.ConclusionThe incidence of CP in Zimbabwe is similar to the rest of the world. Some biochemical components have been noted to be markedly elevated in the cystic fluid and were mirroring serum rather than CSF in concentration. |
| first_indexed | 2024-04-12T17:26:27Z |
| format | Article |
| id | doaj.art-9e082baf06234159903a70d6e7af54bc |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-12T17:26:27Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-9e082baf06234159903a70d6e7af54bc2022-12-22T03:23:18ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-11-01910.3389/fsurg.2022.10269261026926Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort studyLuxwell Jokonya0Tariro Lavender Mduluza-Jokonya1Ignatius Esene2Garikai Mwale3Nqobile Sindiswa Thango4Takafira Mduluza5Thajasvarie Naicker6Surgical Sciences Department, University of Zimbabwe, Harare, ZimbabweDepartment of Optics and Imaging, University of KwaZulu-Natal, Durban, South AfricaDepartment of Surgery, The University of Bamenda, Bambili, CameroonSurgical Sciences Department, University of Zimbabwe, Harare, ZimbabweDepartment of Neurosurgery, University of Cape Town, Cape Town, South AfricaSurgical Sciences Department, University of Zimbabwe, Harare, ZimbabweDepartment of Optics and Imaging, University of KwaZulu-Natal, Durban, South AfricaIntroductionCraniopharyngioma is a rare brain tumour. Despite being histologically benign, it behaves aggressively and is often difficult to manage. Descriptive epidemiological data on the tumour is lacking in sub-Saharan Africa, and there is none for Zimbabwe. The tumour usually has a cystic component that has been raising interest in the past decade. Few studies have looked at the biochemical composition thereof. This study aims to give a landscape view of craniopharyngiomas (CPs) in Zimbabwe and then profile the biochemical properties of the cystic component of paediatric adamantinomatous craniopharyngioma.MethodologyA prospective cohort study was done in Zimbabwe over a 2-year period to study the epidemiological distribution of craniopharyngioma and examine the biochemical composition of adamantinomatous craniopharyngioma cystic fluid in the paediatric population. Fifteen patients were recruited who had craniopharyngiomas, and of those, nine paediatric adamantinomatous craniopharyngiomas had fluid analysed for biochemical components. SPSS statistical package was used to analyse the data. Descriptive statistics were used for epidemiological data.ResultsThe incidence of CP was calculated to be 0.53 per million person-years. Incidence among the paediatric population 0–14 years was 1.2 per 100,000 person-years. Several biological components were found to be elevated significantly compared to serum and cerebral spinal fluid (CSF). These are sodium, potassium, urea, alkaline phosphatase, phosphate, magnesium, albumin, gamma-glutamyl transferase, calcium, low-density lipids, and glucose.ConclusionThe incidence of CP in Zimbabwe is similar to the rest of the world. Some biochemical components have been noted to be markedly elevated in the cystic fluid and were mirroring serum rather than CSF in concentration.https://www.frontiersin.org/articles/10.3389/fsurg.2022.1026926/fullcraniopharyngiomacraniopharyngioma cystic fluidAfrica Zimbabwe brain tumoursantimicrobialssub-Saharan brain tumours |
| spellingShingle | Luxwell Jokonya Tariro Lavender Mduluza-Jokonya Ignatius Esene Garikai Mwale Nqobile Sindiswa Thango Takafira Mduluza Thajasvarie Naicker Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study Frontiers in Surgery craniopharyngioma craniopharyngioma cystic fluid Africa Zimbabwe brain tumours antimicrobials sub-Saharan brain tumours |
| title | Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study |
| title_full | Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study |
| title_fullStr | Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study |
| title_full_unstemmed | Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study |
| title_short | Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study |
| title_sort | biochemical profile of paediatric adamantinomatous craniopharyngiomas a prospective cohort study |
| topic | craniopharyngioma craniopharyngioma cystic fluid Africa Zimbabwe brain tumours antimicrobials sub-Saharan brain tumours |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1026926/full |
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