Non-coding RNA mediates endoplasmic reticulum stress-induced apoptosis in heart disease
Apoptosis is a complex and highly self-regulating form of cell death, which is an important cause of the continuous decline in ventricular function and is widely involved in the occurrence and development of heart failure, myocardial infarction, and myocarditis. Endoplasmic reticulum stress plays a...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023034539 |
| _version_ | 1797815516750938112 |
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| author | Mingyuan Fan Jing Zhang Lei Zeng Danpeng Wang Jiao Chen Xiaorong Xi Jing Long Jinzhu Huang Xueping Li |
| author_facet | Mingyuan Fan Jing Zhang Lei Zeng Danpeng Wang Jiao Chen Xiaorong Xi Jing Long Jinzhu Huang Xueping Li |
| author_sort | Mingyuan Fan |
| collection | DOAJ |
| description | Apoptosis is a complex and highly self-regulating form of cell death, which is an important cause of the continuous decline in ventricular function and is widely involved in the occurrence and development of heart failure, myocardial infarction, and myocarditis. Endoplasmic reticulum stress plays a crucial role in apoptosis-inducing. Accumulation of misfolded or unfolded proteins causes cells to undergo a stress response called unfolded protein response (UPR). UPR initially has a cardioprotective effect. Nevertheless, prolonged and severe ER stress will lead up to apoptosis of stressed cells. Non-coding RNA is a type of RNA that does not code proteins. An ever-increasing number of studies have shown that non-coding RNAs are involved in regulating endoplasmic reticulum stress-induced cardiomyocyte injury and apoptosis. In this study, the effects of miRNA and LncRNA on endoplasmic reticulum stress in various heart diseases were mainly discussed to clarify their protective effects and potential therapeutic strategies for apoptosis. |
| first_indexed | 2024-03-13T08:23:59Z |
| format | Article |
| id | doaj.art-9e09a99af12740ee87c2611ba81c2f27 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:23:59Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-9e09a99af12740ee87c2611ba81c2f272023-05-31T04:47:02ZengElsevierHeliyon2405-84402023-05-0195e16246Non-coding RNA mediates endoplasmic reticulum stress-induced apoptosis in heart diseaseMingyuan Fan0Jing Zhang1Lei Zeng2Danpeng Wang3Jiao Chen4Xiaorong Xi5Jing Long6Jinzhu Huang7Xueping Li8Department of Senile Disease, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaDepartment of Senile Disease, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaDepartment of Senile Disease, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaDepartment of Senile Disease, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaDepartment of Senile Disease, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaDepartment of Senile Disease, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaDepartment of Senile Disease, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaChengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Corresponding author.Department of Senile Disease, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China; Corresponding author.Apoptosis is a complex and highly self-regulating form of cell death, which is an important cause of the continuous decline in ventricular function and is widely involved in the occurrence and development of heart failure, myocardial infarction, and myocarditis. Endoplasmic reticulum stress plays a crucial role in apoptosis-inducing. Accumulation of misfolded or unfolded proteins causes cells to undergo a stress response called unfolded protein response (UPR). UPR initially has a cardioprotective effect. Nevertheless, prolonged and severe ER stress will lead up to apoptosis of stressed cells. Non-coding RNA is a type of RNA that does not code proteins. An ever-increasing number of studies have shown that non-coding RNAs are involved in regulating endoplasmic reticulum stress-induced cardiomyocyte injury and apoptosis. In this study, the effects of miRNA and LncRNA on endoplasmic reticulum stress in various heart diseases were mainly discussed to clarify their protective effects and potential therapeutic strategies for apoptosis.http://www.sciencedirect.com/science/article/pii/S2405844023034539ApoptosisEndoplasmic reticulum stressNon-coding RNAmicroRNAIschemia/reperfusionHeart disease |
| spellingShingle | Mingyuan Fan Jing Zhang Lei Zeng Danpeng Wang Jiao Chen Xiaorong Xi Jing Long Jinzhu Huang Xueping Li Non-coding RNA mediates endoplasmic reticulum stress-induced apoptosis in heart disease Heliyon Apoptosis Endoplasmic reticulum stress Non-coding RNA microRNA Ischemia/reperfusion Heart disease |
| title | Non-coding RNA mediates endoplasmic reticulum stress-induced apoptosis in heart disease |
| title_full | Non-coding RNA mediates endoplasmic reticulum stress-induced apoptosis in heart disease |
| title_fullStr | Non-coding RNA mediates endoplasmic reticulum stress-induced apoptosis in heart disease |
| title_full_unstemmed | Non-coding RNA mediates endoplasmic reticulum stress-induced apoptosis in heart disease |
| title_short | Non-coding RNA mediates endoplasmic reticulum stress-induced apoptosis in heart disease |
| title_sort | non coding rna mediates endoplasmic reticulum stress induced apoptosis in heart disease |
| topic | Apoptosis Endoplasmic reticulum stress Non-coding RNA microRNA Ischemia/reperfusion Heart disease |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023034539 |
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