p16 mutation spectrum in the premalignant condition Barrett's esophagus.
Mutation, promoter hypermethylation and loss of heterozygosity involving the tumor suppressor gene p16 (CDKN2a/INK4a) have been detected in a wide variety of human cancers, but much less is known concerning the frequency and spectrum of p16 mutations in premalignant conditions.We have determined the...
| Main Authors: | , , , , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
Public Library of Science (PLoS)
2008-01-01
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| 叢編: | PLoS ONE |
| 在線閱讀: | http://europepmc.org/articles/PMC2585012?pdf=render |