p16 mutation spectrum in the premalignant condition Barrett's esophagus.

p16 mutation spectrum in the premalignant condition Barrett's esophagus.

Mutation, promoter hypermethylation and loss of heterozygosity involving the tumor suppressor gene p16 (CDKN2a/INK4a) have been detected in a wide variety of human cancers, but much less is known concerning the frequency and spectrum of p16 mutations in premalignant conditions.We have determined the...

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Bibliographic Details
Main Authors: Thomas G Paulson, Patricia C Galipeau, Lianjun Xu, Heather D Kissel, Xiaohong Li, Patricia L Blount, Carissa A Sanchez, Robert D Odze, Brian J Reid
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2585012?pdf=render

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