p16 mutation spectrum in the premalignant condition Barrett's esophagus.

p16 mutation spectrum in the premalignant condition Barrett's esophagus.

Mutation, promoter hypermethylation and loss of heterozygosity involving the tumor suppressor gene p16 (CDKN2a/INK4a) have been detected in a wide variety of human cancers, but much less is known concerning the frequency and spectrum of p16 mutations in premalignant conditions.We have determined the...

Полное описание

Библиографические подробности
Главные авторы: Thomas G Paulson, Patricia C Galipeau, Lianjun Xu, Heather D Kissel, Xiaohong Li, Patricia L Blount, Carissa A Sanchez, Robert D Odze, Brian J Reid
Формат: Статья
Язык:English
Опубликовано: Public Library of Science (PLoS) 2008-01-01
Серии:PLoS ONE
Online-ссылка:http://europepmc.org/articles/PMC2585012?pdf=render

Internet

http://europepmc.org/articles/PMC2585012?pdf=render

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