Allopurinol-induced Agranulocytosis: A Case Report and Review
Allopurinol, utilized in the treatment of gouty arthritis and hyperuricemia, is one of the most prescribed medications in general medical practice. Although well-tolerated, allopurinol can cause rare and severe adverse reactions, including bone marrow toxicity. A 68-year-old man presented to the hos...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Department of Medicine, Warren Alpert Medical School at Brown University
2022-11-01
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| Series: | Brown Journal of Hospital Medicine |
| Online Access: | https://bhm.scholasticahq.com/article/39749-allopurinol-induced-agranulocytosis-a-case-report-and-review |
| _version_ | 1811211634132123648 |
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| author | Aswanth Reddy Arjun Sekar Nkolika Nwankwo Aswini Kumar |
| author_facet | Aswanth Reddy Arjun Sekar Nkolika Nwankwo Aswini Kumar |
| author_sort | Aswanth Reddy |
| collection | DOAJ |
| description | Allopurinol, utilized in the treatment of gouty arthritis and hyperuricemia, is one of the most prescribed medications in general medical practice. Although well-tolerated, allopurinol can cause rare and severe adverse reactions, including bone marrow toxicity. A 68-year-old man presented to the hospital with severe neutropenia and aseptic meningitis. After an extensive workup, allopurinol was determined to be the culprit medication causing severe agranulocytosis, and his blood counts recovered upon discontinuing the drug. Drug-induced agranulocytosis is a rare but serious adverse reaction. Treatment includes supportive care and discontinuation of the offending agent. |
| first_indexed | 2024-04-12T05:16:12Z |
| format | Article |
| id | doaj.art-9e0d4f10f64e4cf1a30a6b1f955a825a |
| institution | Directory Open Access Journal |
| issn | 2831-5553 |
| language | English |
| last_indexed | 2024-04-12T05:16:12Z |
| publishDate | 2022-11-01 |
| publisher | Department of Medicine, Warren Alpert Medical School at Brown University |
| record_format | Article |
| series | Brown Journal of Hospital Medicine |
| spelling | doaj.art-9e0d4f10f64e4cf1a30a6b1f955a825a2022-12-22T03:46:37ZengDepartment of Medicine, Warren Alpert Medical School at Brown UniversityBrown Journal of Hospital Medicine2831-55532022-11-0114Allopurinol-induced Agranulocytosis: A Case Report and ReviewAswanth ReddyArjun SekarNkolika NwankwoAswini KumarAllopurinol, utilized in the treatment of gouty arthritis and hyperuricemia, is one of the most prescribed medications in general medical practice. Although well-tolerated, allopurinol can cause rare and severe adverse reactions, including bone marrow toxicity. A 68-year-old man presented to the hospital with severe neutropenia and aseptic meningitis. After an extensive workup, allopurinol was determined to be the culprit medication causing severe agranulocytosis, and his blood counts recovered upon discontinuing the drug. Drug-induced agranulocytosis is a rare but serious adverse reaction. Treatment includes supportive care and discontinuation of the offending agent.https://bhm.scholasticahq.com/article/39749-allopurinol-induced-agranulocytosis-a-case-report-and-review |
| spellingShingle | Aswanth Reddy Arjun Sekar Nkolika Nwankwo Aswini Kumar Allopurinol-induced Agranulocytosis: A Case Report and Review Brown Journal of Hospital Medicine |
| title | Allopurinol-induced Agranulocytosis: A Case Report and Review |
| title_full | Allopurinol-induced Agranulocytosis: A Case Report and Review |
| title_fullStr | Allopurinol-induced Agranulocytosis: A Case Report and Review |
| title_full_unstemmed | Allopurinol-induced Agranulocytosis: A Case Report and Review |
| title_short | Allopurinol-induced Agranulocytosis: A Case Report and Review |
| title_sort | allopurinol induced agranulocytosis a case report and review |
| url | https://bhm.scholasticahq.com/article/39749-allopurinol-induced-agranulocytosis-a-case-report-and-review |
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