Sex‐Specific Comparison Between Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict New‐Onset Hypertension in Middle‐Aged and Older Adults

Background Triglyceride and glucose (TyG) index and TyG‐related indices combined with obesity‐related markers are considered important markers of insulin resistance. We aimed to examine the association between the TyG index and modified TyG indices with new‐onset hypertension and their predictive ab...

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Main Authors: Joo Hyung Lee, Seok‐Jae Heo, Yu‐Jin Kwon
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.030022
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author Joo Hyung Lee
Seok‐Jae Heo
Yu‐Jin Kwon
author_facet Joo Hyung Lee
Seok‐Jae Heo
Yu‐Jin Kwon
author_sort Joo Hyung Lee
collection DOAJ
description Background Triglyceride and glucose (TyG) index and TyG‐related indices combined with obesity‐related markers are considered important markers of insulin resistance. We aimed to examine the association between the TyG index and modified TyG indices with new‐onset hypertension and their predictive ability stratified by sex. Methods and Results We analyzed data from 5414 Korean Genome and Epidemiology Study participants aged 40 to 69 years. Multiple Cox proportional hazard regression analyses were conducted to estimate the hazard ratio (HR) and 95% CI for new‐onset hypertension according to sex‐specific tertile groups after confounder adjustments. To evaluate the predictive performance of these indices for new‐onset hypertension, we calculated Harrell's C‐index (95% CI). Over a 9.5‐year follow‐up period, 1014 men and 1012 women developed new‐onset hypertension. Compared with the lowest tertile (T) group, the adjusted HR and 95% CI for new‐onset hypertension in T3 for TyG, TyG‐body mass index, TyG‐waist circumference, and TyG‐waist‐to‐height ratio were 1.16 (0.95–1.40), 1.11 (0.84–1.48), 1.77 (1.38–2.27), and 1.68 (1.33–2.13) in men and 1.37 (1.13–1.66), 1.55 (1.16–2.06), 1.43 (1.15–1.79), and 1.64 (1.30–2.07) in women, respectively. The C‐indices of TyG‐waist‐to‐height ratio for new‐onset hypertension were significantly higher than those of TyG and TyG‐body mass index in both men and women. Conclusions TyG and TyG‐body mass index were significantly associated with new‐onset hypertension only in women. TyG‐waist circumference and TyG‐waist‐to‐height ratio were significantly associated with new‐onset hypertension in both men and women. A sex‐specific approach is required when using TyG and modified TyG indices to identify individuals at risk of incident hypertension.
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spelling doaj.art-9e0e1d32a60b43e69363cabea16d33352023-11-10T10:23:41ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-09-01121810.1161/JAHA.123.030022Sex‐Specific Comparison Between Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict New‐Onset Hypertension in Middle‐Aged and Older AdultsJoo Hyung Lee0Seok‐Jae Heo1Yu‐Jin Kwon2Department of Family Medicine, Yongin Severance Hospital Yonsei University College of Medicine Yongin Republic of KoreaDivision of Biostatistics, Department of Biomedical Systems Informatics Yonsei University College of Medicine Seoul Republic of KoreaDepartment of Family Medicine, Yongin Severance Hospital Yonsei University College of Medicine Yongin Republic of KoreaBackground Triglyceride and glucose (TyG) index and TyG‐related indices combined with obesity‐related markers are considered important markers of insulin resistance. We aimed to examine the association between the TyG index and modified TyG indices with new‐onset hypertension and their predictive ability stratified by sex. Methods and Results We analyzed data from 5414 Korean Genome and Epidemiology Study participants aged 40 to 69 years. Multiple Cox proportional hazard regression analyses were conducted to estimate the hazard ratio (HR) and 95% CI for new‐onset hypertension according to sex‐specific tertile groups after confounder adjustments. To evaluate the predictive performance of these indices for new‐onset hypertension, we calculated Harrell's C‐index (95% CI). Over a 9.5‐year follow‐up period, 1014 men and 1012 women developed new‐onset hypertension. Compared with the lowest tertile (T) group, the adjusted HR and 95% CI for new‐onset hypertension in T3 for TyG, TyG‐body mass index, TyG‐waist circumference, and TyG‐waist‐to‐height ratio were 1.16 (0.95–1.40), 1.11 (0.84–1.48), 1.77 (1.38–2.27), and 1.68 (1.33–2.13) in men and 1.37 (1.13–1.66), 1.55 (1.16–2.06), 1.43 (1.15–1.79), and 1.64 (1.30–2.07) in women, respectively. The C‐indices of TyG‐waist‐to‐height ratio for new‐onset hypertension were significantly higher than those of TyG and TyG‐body mass index in both men and women. Conclusions TyG and TyG‐body mass index were significantly associated with new‐onset hypertension only in women. TyG‐waist circumference and TyG‐waist‐to‐height ratio were significantly associated with new‐onset hypertension in both men and women. A sex‐specific approach is required when using TyG and modified TyG indices to identify individuals at risk of incident hypertension.https://www.ahajournals.org/doi/10.1161/JAHA.123.030022body mass indexhypertensiontriglyceride and glucose index
spellingShingle Joo Hyung Lee
Seok‐Jae Heo
Yu‐Jin Kwon
Sex‐Specific Comparison Between Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict New‐Onset Hypertension in Middle‐Aged and Older Adults
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
body mass index
hypertension
triglyceride and glucose index
title Sex‐Specific Comparison Between Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict New‐Onset Hypertension in Middle‐Aged and Older Adults
title_full Sex‐Specific Comparison Between Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict New‐Onset Hypertension in Middle‐Aged and Older Adults
title_fullStr Sex‐Specific Comparison Between Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict New‐Onset Hypertension in Middle‐Aged and Older Adults
title_full_unstemmed Sex‐Specific Comparison Between Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict New‐Onset Hypertension in Middle‐Aged and Older Adults
title_short Sex‐Specific Comparison Between Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict New‐Onset Hypertension in Middle‐Aged and Older Adults
title_sort sex specific comparison between triglyceride glucose index and modified triglyceride glucose indices to predict new onset hypertension in middle aged and older adults
topic body mass index
hypertension
triglyceride and glucose index
url https://www.ahajournals.org/doi/10.1161/JAHA.123.030022
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