Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections
Abstract The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant chall...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-43415-8 |
| _version_ | 1827709910912073728 |
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| author | Jian Cheng Guihai Gan Shaoqiu Zheng Guoying Zhang Chen Zhu Shiyong Liu Jinming Hu |
| author_facet | Jian Cheng Guihai Gan Shaoqiu Zheng Guoying Zhang Chen Zhu Shiyong Liu Jinming Hu |
| author_sort | Jian Cheng |
| collection | DOAJ |
| description | Abstract The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Herein, we report the fabrication of micellar nanoparticles adapted to heterogeneous biofilm microenvironments, enabling nitric oxide (NO) release through two distinct photoredox catalysis mechanisms. The key design feature involves the use of tertiary amine (TA) moieties, which function as sacrificial agents to avoid the quenching of photocatalysts under normoxic and neutral pH conditions and proton acceptors at acidic pH to allow deep biofilm penetration. This biofilm-adaptive NO-releasing platform shows excellent antibiofilm activity against ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) biofilms both in vitro and in a mouse skin infection model, providing a strategy for combating biofilm heterogeneity and biofilm-related infections. |
| first_indexed | 2024-03-10T17:29:54Z |
| format | Article |
| id | doaj.art-9e10beb896cb453a8f465a8d6661f30d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:29:54Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9e10beb896cb453a8f465a8d6661f30d2023-11-20T10:03:15ZengNature PortfolioNature Communications2041-17232023-11-0114111210.1038/s41467-023-43415-8Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infectionsJian Cheng0Guihai Gan1Shaoqiu Zheng2Guoying Zhang3Chen Zhu4Shiyong Liu5Jinming Hu6Department of Orthopedics, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of ChinaDepartment of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), and Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of ChinaDepartment of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), and Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of ChinaDepartment of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), and Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of ChinaDepartment of Orthopedics, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of ChinaDepartment of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), and Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of ChinaDepartment of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), and Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of ChinaAbstract The formation of biofilms is closely associated with persistent and chronic infections, and physiological heterogeneity such as pH and oxygen gradients renders biofilms highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Herein, we report the fabrication of micellar nanoparticles adapted to heterogeneous biofilm microenvironments, enabling nitric oxide (NO) release through two distinct photoredox catalysis mechanisms. The key design feature involves the use of tertiary amine (TA) moieties, which function as sacrificial agents to avoid the quenching of photocatalysts under normoxic and neutral pH conditions and proton acceptors at acidic pH to allow deep biofilm penetration. This biofilm-adaptive NO-releasing platform shows excellent antibiofilm activity against ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) biofilms both in vitro and in a mouse skin infection model, providing a strategy for combating biofilm heterogeneity and biofilm-related infections.https://doi.org/10.1038/s41467-023-43415-8 |
| spellingShingle | Jian Cheng Guihai Gan Shaoqiu Zheng Guoying Zhang Chen Zhu Shiyong Liu Jinming Hu Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections Nature Communications |
| title | Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections |
| title_full | Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections |
| title_fullStr | Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections |
| title_full_unstemmed | Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections |
| title_short | Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections |
| title_sort | biofilm heterogeneity adaptive photoredox catalysis enables red light triggered nitric oxide release for combating drug resistant infections |
| url | https://doi.org/10.1038/s41467-023-43415-8 |
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