Pim Kinases: Important Regulators of Cardiovascular Disease
Pim Kinases; Pim-1, Pim-2, and Pim-3, are a family of constitutively active serine/threonine kinases, widely associated with cell survival, proliferation, and migration. Historically considered to be functionally redundant, independent roles for the individual isoforms have been described. Whilst mo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/14/11582 |
| _version_ | 1797588989691035648 |
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| author | Sophie Nock Eima Karim Amanda J. Unsworth |
| author_facet | Sophie Nock Eima Karim Amanda J. Unsworth |
| author_sort | Sophie Nock |
| collection | DOAJ |
| description | Pim Kinases; Pim-1, Pim-2, and Pim-3, are a family of constitutively active serine/threonine kinases, widely associated with cell survival, proliferation, and migration. Historically considered to be functionally redundant, independent roles for the individual isoforms have been described. Whilst most established for their role in cancer progression, there is increasing evidence for wider pathological roles of Pim kinases within the context of cardiovascular disease, including inflammation, thrombosis, and cardiac injury. The Pim kinase isoforms have widespread expression in cardiovascular tissues, including the heart, coronary artery, aorta, and blood, and have been demonstrated to be upregulated in several co-morbidities/risk factors for cardiovascular disease. Pim kinase inhibition may thus be a desirable therapeutic for a multi-targeted approach to treat cardiovascular disease and some of the associated risk factors. In this review, we discuss what is known about Pim kinase expression and activity in cells of the cardiovascular system, identify areas where the role of Pim kinase has yet to be fully explored and characterised and review the suitability of targeting Pim kinase for the prevention and treatment of cardiovascular events in high-risk individuals. |
| first_indexed | 2024-03-11T01:00:52Z |
| format | Article |
| id | doaj.art-9e10eb54fdd140798c541b1137c032ac |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:00:52Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9e10eb54fdd140798c541b1137c032ac2023-11-18T19:41:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124141158210.3390/ijms241411582Pim Kinases: Important Regulators of Cardiovascular DiseaseSophie Nock0Eima Karim1Amanda J. Unsworth2Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester M1 5GD, UKDepartment of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester M1 5GD, UKDepartment of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester M1 5GD, UKPim Kinases; Pim-1, Pim-2, and Pim-3, are a family of constitutively active serine/threonine kinases, widely associated with cell survival, proliferation, and migration. Historically considered to be functionally redundant, independent roles for the individual isoforms have been described. Whilst most established for their role in cancer progression, there is increasing evidence for wider pathological roles of Pim kinases within the context of cardiovascular disease, including inflammation, thrombosis, and cardiac injury. The Pim kinase isoforms have widespread expression in cardiovascular tissues, including the heart, coronary artery, aorta, and blood, and have been demonstrated to be upregulated in several co-morbidities/risk factors for cardiovascular disease. Pim kinase inhibition may thus be a desirable therapeutic for a multi-targeted approach to treat cardiovascular disease and some of the associated risk factors. In this review, we discuss what is known about Pim kinase expression and activity in cells of the cardiovascular system, identify areas where the role of Pim kinase has yet to be fully explored and characterised and review the suitability of targeting Pim kinase for the prevention and treatment of cardiovascular events in high-risk individuals.https://www.mdpi.com/1422-0067/24/14/11582Pim kinasecardiovascular diseaseatherosclerosis |
| spellingShingle | Sophie Nock Eima Karim Amanda J. Unsworth Pim Kinases: Important Regulators of Cardiovascular Disease International Journal of Molecular Sciences Pim kinase cardiovascular disease atherosclerosis |
| title | Pim Kinases: Important Regulators of Cardiovascular Disease |
| title_full | Pim Kinases: Important Regulators of Cardiovascular Disease |
| title_fullStr | Pim Kinases: Important Regulators of Cardiovascular Disease |
| title_full_unstemmed | Pim Kinases: Important Regulators of Cardiovascular Disease |
| title_short | Pim Kinases: Important Regulators of Cardiovascular Disease |
| title_sort | pim kinases important regulators of cardiovascular disease |
| topic | Pim kinase cardiovascular disease atherosclerosis |
| url | https://www.mdpi.com/1422-0067/24/14/11582 |
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